Willard M. Freeman

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 83	2015
Publication title Cited by 2	2023

Other Publications

Article	Year
Changes in rat frontal cortex gene expression following chronic cocaine. Brain research. Molecular brain research\| PubMed ID: 12117546	2002
Repeated cocaine self-administration causes multiple changes in rat frontal cortex gene expression. Neurochemical research\| PubMed ID: 12462416	2002
Systematic screening of gene expression using a cDNA macroarray. Methods in molecular medicine\| PubMed ID: 12506701	2003
Induction of GADD45 and GADD153 in neuroblastoma cells by dopamine-induced toxicity. Neurotoxicology\| PubMed ID: 12520757	2002
Use of microarray technologies in toxicology research. Neurotoxicology\| PubMed ID: 12782098	2003
An interactive database of cocaine-responsive gene expression. TheScientificWorldJournal\| PubMed ID: 12805995	2002
Functional genomic analysis in pain research using hybridization arrays. Methods in molecular medicine\| PubMed ID: 15131342	2004
Alterations in ionotropic glutamate receptor subunits during binge cocaine self-administration and withdrawal in rats. Journal of neurochemistry\| PubMed ID: 15140200	2004
Proteomics for protein expression profiling in neuroscience. Neurochemical research\| PubMed ID: 15176464	2004
Manganese-induced cytotoxicity in dopamine-producing cells. Neurotoxicology\| PubMed ID: 15183009	2004
Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. Journal of neuroscience research\| PubMed ID: 15846778	2005
Apo-AII is an elevated biomarker of chronic non-human primate ethanol self-administration. Alcohol and alcoholism (Oxford, Oxfordshire)\| PubMed ID: 16581821	2006
Depletion of abundant proteins from non-human primate serum for biomarker studies. Proteomics\| PubMed ID: 16619306	2006
Diabetic retinopathy: seeing beyond glucose-induced microvascular disease. Diabetes\| PubMed ID: 16936187	2006
Plasma proteomics: a noninvasive window on pathology and pediatric cardiac surgery. ASAIO journal (American Society for Artificial Internal Organs : 1992)\| PubMed ID: 16966860	2006
Persistent alterations in mesolimbic gene expression with abstinence from cocaine self-administration. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology\| PubMed ID: 17851536	2008
Plasma biomarkers in pediatric patients undergoing cardiopulmonary bypass. Pediatric research\| PubMed ID: 18317239	2008
Heroin self-administration: II. CNS gene expression following withdrawal and cue-induced drug-seeking behavior. Pharmacology, biochemistry, and behavior\| PubMed ID: 18466961	2008
Twenty-five years of quantitative PCR for gene expression analysis. BioTechniques\| PubMed ID: 18474036	2008
Whole genome assessment of the retinal response to diabetes reveals a progressive neurovascular inflammatory response. BMC medical genomics\| PubMed ID: 18554398	2008
Diabetes downregulates presynaptic proteins and reduces basal synapsin I phosphorylation in rat retina. The European journal of neuroscience\| PubMed ID: 18662330	2008
Human embryonic and mesenchymal stem cells express different nuclear proteomes. Stem cells and development\| PubMed ID: 18821827	2009
Age-related changes in the expression and oxidation of bronchoalveolar lavage proteins in the rat. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 18931054	2009
Correlating human and animal studies of cocaine abuse and gene expression. Annals of the New York Academy of Sciences\| PubMed ID: 18991951	2008
Gene expression profiles in HPV-immortalized human cervical cells treated with the nicotine-derived carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Chemico-biological interactions\| PubMed ID: 19038236	2009
The retinal proteome in experimental diabetic retinopathy: up-regulation of crystallins and reversal by systemic and periocular insulin. Molecular & cellular proteomics : MCP\| PubMed ID: 19049959	2009
The impact of surfactant protein-A on ozone-induced changes in the mouse bronchoalveolar lavage proteome. Proteome science\| PubMed ID: 19323824	2009
Pediatric cardiopulmonary bypass circuits: a review of studies conducted at the Penn State Pediatric Cardiac Research Laboratories. The Journal of extra-corporeal technology\| PubMed ID: 19361042	2009
FOXO3a elicits a pro-apoptotic transcription program and cellular response to human lung carcinogen nicotine-derived nitrosaminoketone (NNK). Lung cancer (Amsterdam, Netherlands)\| PubMed ID: 19380174	2010
Gene expression changes following extinction testing in a heroin behavioral incubation model. BMC neuroscience\| PubMed ID: 19664213	2009
The use of neuroproteomics in drug abuse research. Drug and alcohol dependence\| PubMed ID: 19926406	2010
Circulating cytokines as biomarkers of alcohol abuse and alcoholism. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology\| PubMed ID: 20020329	2010
Transcriptomic comparison of the retina in two mouse models of diabetes. Journal of ocular biology, diseases, and informatics\| PubMed ID: 20157355	2009
Persistent proteomic alterations in the medial prefrontal cortex with abstinence from cocaine self-administration. Proteomics. Clinical applications\| PubMed ID: 20161123	2009
Gene expression changes in the medial prefrontal cortex and nucleus accumbens following abstinence from cocaine self-administration. BMC neuroscience\| PubMed ID: 20187946	2010
Classification of alcohol abuse by plasma protein biomarkers. Biological psychiatry\| PubMed ID: 20299005	2010
Dual-platform proteomics study of plasma biomarkers in pediatric patients undergoing cardiopulmonary bypass. Pediatric research\| PubMed ID: 20308938	2010
Future prospects for biomarkers of alcohol consumption and alcohol-induced disorders. Alcoholism, clinical and experimental research\| PubMed ID: 20374220	2010
Aging alters the expression of neurotransmission-regulating proteins in the hippocampal synaptoproteome. Journal of neurochemistry\| PubMed ID: 20374424	2010
Effects of ischemic preconditioning and bevacizumab on apoptosis and vascular permeability following retinal ischemia-reperfusion injury. Investigative ophthalmology & visual science\| PubMed ID: 20554620	2010
Differences in the BAL proteome after Klebsiella pneumoniae infection in wild type and SP-A-/- mice. Proteome science\| PubMed ID: 20565803	2010
Clinical application for the preservation of phospho-proteins through in-situ tissue stabilization. Proteome science\| PubMed ID: 21092202	2010
Individual differences in hyperlipidemia and vitamin E status in response to chronic alcohol self-administration in cynomolgus monkeys. Alcoholism, clinical and experimental research\| PubMed ID: 21118275	2011
2-D DIGE identification of differentially expressed heterogeneous nuclear ribonucleoproteins and transcription factors during neural differentiation of human embryonic stem cells. Proteomics. Clinical applications\| PubMed ID: 21136975	2009
Multi-modal proteomic analysis of retinal protein expression alterations in a rat model of diabetic retinopathy. PloS one\| PubMed ID: 21249158	2011
TPH2 in the ventral tegmental area of the male rat brain. Brain research bulletin\| PubMed ID: 21272616	2011
Plasma proteomic alterations in non-human primates and humans after chronic alcohol self-administration. The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP)\| PubMed ID: 21303580	2011
Hippocampal dysregulation of synaptic plasticity-associated proteins with age-related cognitive decline. Neurobiology of disease\| PubMed ID: 21440628	2011
Chronic insulin treatment of diabetes does not fully normalize alterations in the retinal transcriptome. BMC medical genomics\| PubMed ID: 21575160	2011
Age-related alterations in retinal neurovascular and inflammatory transcripts. Molecular vision\| PubMed ID: 21633715	2011
The hippocampal neuroproteome with aging and cognitive decline: past progress and future directions. Frontiers in aging neuroscience\| PubMed ID: 21647399	2011
Circulating IGF1 regulates hippocampal IGF1 levels and brain gene expression during adolescence. The Journal of endocrinology\| PubMed ID: 21750148	2011
Concurrent hippocampal induction of MHC II pathway components and glial activation with advanced aging is not correlated with cognitive impairment. Journal of neuroinflammation\| PubMed ID: 21989322	2011
A Longitudinal Analysis of Circulating Stress-Related Proteins and Chronic Ethanol Self-Administration in Cynomolgus Macaques. Alcoholism, clinical and experimental research\| PubMed ID: 22141444	2011
The kinetics of cardiopulmonary bypass: a dual-platform proteomics study of plasma biomarkers in pediatric patients undergoing cardiopulmonary bypass. Artificial organs\| PubMed ID: 22250822	2012
Hippocampal expression of myelin-associated inhibitors is induced with age-related cognitive decline and correlates with deficits of spatial learning and memory. Journal of neurochemistry\| PubMed ID: 22269040	2012
Nanoliposomal minocycline for ocular drug delivery. Nanomedicine : nanotechnology, biology, and medicine\| PubMed ID: 22465498	2013
Neuroglial expression of the MHCI pathway and PirB receptor is upregulated in the hippocampus with advanced aging. Journal of molecular neuroscience : MN\| PubMed ID: 22562814	2012
Quantification of Hepatic UDP glucuronosyltransferase 1A splice variant expression and correlation of UDP glucuronosyltransferase 1A1 variant expression with glucuronidation activity. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 22661630	2012
Protein biomarkers of alcohol abuse. Expert review of proteomics\| PubMed ID: 22967079	2012
Increased hippocampal NgR1 signaling machinery in aged rats with deficits of spatial cognition. The European journal of neuroscience\| PubMed ID: 23438185	2013
Expression of NgR1-antagonizing proteins decreases with aging and cognitive decline in rat hippocampus. Cellular and molecular neurobiology\| PubMed ID: 23525710	2013
Focused, high accuracy 5-methylcytosine quantitation with base resolution by benchtop next-generation sequencing. Epigenetics & chromatin\| PubMed ID: 24279302	2013
Integrative transcriptomic and proteomic analysis of osteocytic cells exposed to fluid flow reveals novel mechano-sensitive signaling pathways. Journal of biomechanics\| PubMed ID: 24720889	2014
Insulin treatment normalizes retinal neuroinflammation but not markers of synapse loss in diabetic rats. Experimental eye research\| PubMed ID: 24931083	2014
Hippocampal subregions exhibit both distinct and shared transcriptomic responses to aging and nonneurodegenerative cognitive decline. The journals of gerontology. Series A, Biological sciences and medical sciences\| PubMed ID: 24994846	2014
Detrimental effects of duplicate reads and low complexity regions on RNA- and ChIP-seq data. BMC bioinformatics\| PubMed ID: 26423047	2015
CNS-wide Sexually Dimorphic Induction of the Major Histocompatibility Complex 1 Pathway With Aging. The journals of gerontology. Series A, Biological sciences and medical sciences\| PubMed ID: 26786204	2016
Bisulfite oligonucleotide-capture sequencing for targeted base- and strand-specific absolute 5-methylcytosine quantitation. Age (Dordrecht, Netherlands)\| PubMed ID: 27091453	2016
Loss of the antioxidant enzyme CuZnSOD (Sod1) mimics an age-related increase in absolute mitochondrial DNA copy number in the skeletal muscle. Age (Dordrecht, Netherlands)\| PubMed ID: 27444179	2016
Role of DNA methylation in the dietary restriction mediated cellular memory. GeroScience\| PubMed ID: 28477138	2017
Functional changes in the neural retina occur in the absence of mitochondrial dysfunction in a rodent model of diabetic retinopathy. Journal of neurochemistry\| PubMed ID: 28902411	2017
Sexually divergent DNA methylation patterns with hippocampal aging. Aging cell\| PubMed ID: 28948711	2017
Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-β uptake in astrocytes. Molecular metabolism\| PubMed ID: 29398615	2018
Obesity in Aging Exacerbates Neuroinflammation, Dysregulating Synaptic Function-Related Genes and Altering Eicosanoid Synthesis in the Mouse Hippocampus: Potential Role in Impaired Synaptic ... The journals of gerontology. Series A, Biological sciences and medical sciences\| PubMed ID: 29893815	2019
The role of DNA methylation in epigenetics of aging. Pharmacology & therapeutics\| PubMed ID: 30419258	2019
Mitochondrial oxidative stress impairs contractile function but paradoxically increases muscle mass via fibre branching. Journal of cachexia, sarcopenia and muscle\| PubMed ID: 30706998	2019
Short-term Calorie Restriction and 17α-Estradiol Administration Elicit Divergent Effects on Proteostatic Processes and Protein Content in Metabolically Active Tissues. The journals of gerontology. Series A, Biological sciences and medical sciences\| PubMed ID: 31074767	2020
Molecular changes in transcription and metabolic pathways underlying muscle atrophy in the CuZnSOD null mouse model of sarcopenia. GeroScience\| PubMed ID: 32394347	2020
Opposite Roles of the JMJD1A Interaction Partners MDFI and MDFIC in Colorectal Cancer. Scientific reports\| PubMed ID: 32457453	2020
Exercising your mind. Science (New York, N.Y.)\| PubMed ID: 32646988	2020
Female mice are resilient to age-related decline of substantia nigra dopamine neuron firing parameters. Neurobiology of aging\| PubMed ID: 32846275	2020
Cooperation between ETS transcription factor ETV1 and histone demethylase JMJD1A in colorectal cancer. International journal of oncology\| PubMed ID: 33174020	2020
Inducible cell-specific mouse models for paired epigenetic and transcriptomic studies of microglia and astroglia. Communications biology\| PubMed ID: 33214681	2020
Health benefits attributed to 17α-estradiol, a lifespan-extending compound, are mediated through estrogen receptor α. eLife\| PubMed ID: 33289482	2020
Cellular hallmarks of aging emerge in the ovary prior to primordial follicle depletion. Mechanisms of ageing and development\| PubMed ID: 33383072	2021
Cigarette Smoke Activates NOTCH3 to Promote Goblet Cell Differentiation in Human Airway Epithelial Cells. American journal of respiratory cell and molecular biology\| PubMed ID: 33444514	2021
Long-term, induced expression of Hand2 in peripheral sympathetic neurons ameliorates sarcopenia in geriatric mice. Journal of cachexia, sarcopenia and muscle\| PubMed ID: 34546662	2021
Litter expansion alters metabolic homeostasis in a sex specific manner. PloS one\| PubMed ID: 34587168	2021
Oklahoma Nathan Shock Aging Center - assessing the basic biology of aging from genetics to protein and function. GeroScience\| PubMed ID: 34606039	2021
Many chronological aging clocks can be found throughout the epigenome: Implications for quantifying biological aging. Aging cell\| PubMed ID: 34655509	2021
Repeated cocaine or methamphetamine treatment alters astrocytic CRF2 and GLAST expression in the ventral midbrain. Addiction biology\| PubMed ID: 34825430	2022
The NOTCH3 Downstream Target HEYL Is Required for Efficient Human Airway Basal Cell Differentiation. Cells\| PubMed ID: 34831437	2021
Scavenging mitochondrial hydrogen peroxide by peroxiredoxin 3 overexpression attenuates contractile dysfunction and muscle atrophy in a murine model of accelerated sarcopenia. Aging cell\| PubMed ID: 35199907	2022
Minimizing the Confounds of Cell-Isolation Techniques on Transcriptomic and Translatomic Profiles of Purified Microglia. eNeuro\| PubMed ID: 35228310	2022
Differential Regulation of Mouse Hippocampal Gene Expression Sex Differences by Chromosomal Content and Gonadal Sex. Molecular neurobiology\| PubMed ID: 35589920	2022
An RNA-seq study of the mPFC of rats with different addiction phenotypes. Brain research bulletin\| PubMed ID: 36223840	2022
Translatomic response of retinal Müller glia to acute and chronic stress. Neurobiology of disease\| PubMed ID: 36423879	2022
17α-estradiol, a lifespan-extending compound, attenuates liver fibrosis by modulating collagen turnover rates in male mice. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 36516471	2023
Isolation of Neuronal Synaptic Membranes by Sucrose Gradient Centrifugation. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 36653629	2023
Chromosomal and gonadal factors regulate microglial sex effects in the aging brain. Brain research bulletin\| PubMed ID: 36804773	2023