Bruno Kyewski

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 15	2015

Other Publications

Article	Year
Promiscuous gene expression and central T-cell tolerance: more than meets the eye. Trends in immunology\| PubMed ID: 12103357	2002
Dynamic changes during the immune response in T cell-antigen-presenting cell clusters isolated from lymph nodes. The Journal of experimental medicine\| PubMed ID: 12566411	2003
Bone marrow as a priming site for T-cell responses to blood-borne antigen. Nature medicine\| PubMed ID: 12910264	2003
Medullary epithelial cells of the human thymus express a highly diverse selection of tissue-specific genes colocalized in chromosomal clusters. The Journal of experimental medicine\| PubMed ID: 14734521	2004
CREB function is required for normal thymic cellularity and post-irradiation recovery. European journal of immunology\| PubMed ID: 15214044	2004
Self-representation in the thymus: an extended view. Nature reviews. Immunology\| PubMed ID: 15343368	2004
Bone marrow microenvironment facilitating dendritic cell: CD4 T cell interactions and maintenance of CD4 memory. International journal of oncology\| PubMed ID: 15375534	2004
Regulating self-tolerance by deregulating gene expression. Current opinion in immunology\| PubMed ID: 15511667	2004
Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels. The Journal of experimental medicine\| PubMed ID: 15983066	2005
Expression of a natural tumor antigen by thymic epithelial cells impairs the tumor-protective CD4+ T-cell repertoire. Cancer research\| PubMed ID: 16024649	2005
Linking signalling pathways, thymic stroma integrity and autoimmunity. Trends in immunology\| PubMed ID: 16039157	2005
Conflicts of interest: the responsibility of the authors and editors of the International Journal of Cancer. International journal of cancer. Journal international du cancer\| PubMed ID: 16482565	2006
A central role for central tolerance. Annual review of immunology\| PubMed ID: 16551260	2006
Foxp3+ CD25+ regulatory T cells specific for a neo-self-antigen develop at the double-positive thymic stage. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16709665	2006
Expression profiling of autoimmune regulator AIRE mRNA in a comprehensive set of human normal and neoplastic tissues. Immunology letters\| PubMed ID: 16876259	2006
Highly variable expression of tissue-restricted self-antigens in human thymus: implications for self-tolerance and autoimmunity. European journal of immunology\| PubMed ID: 17323415	2007
Expression of tumor-associated differentiation antigens, MUC1 glycoforms and CEA, in human thymic epithelial cells: implications for self-tolerance and tumor therapy. Cancer research\| PubMed ID: 17440107	2007
An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus. Nature\| PubMed ID: 17687331	2007
Promiscuous gene expression and the developmental dynamics of medullary thymic epithelial cells. European journal of immunology\| PubMed ID: 18000951	2007
Promiscuous gene expression patterns in single medullary thymic epithelial cells argue for a stochastic mechanism. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18180458	2008
How promiscuity promotes tolerance: the case of myasthenia gravis. Annals of the New York Academy of Sciences\| PubMed ID: 18567865	2008
Immunology. A breath of Aire for the periphery. Science (New York, N.Y.)\| PubMed ID: 18687943	2008
The thymus medulla slowly yields its secrets. Annals of the New York Academy of Sciences\| PubMed ID: 19076347	2008
The thymic medulla: a unique microenvironment for intercellular self-antigen transfer. The Journal of experimental medicine\| PubMed ID: 19564355	2009
Obligation for cell line authentication: appeal for concerted action. International journal of cancer. Journal international du cancer\| PubMed ID: 19882693	2010
Antigen presentation in the thymus for positive selection and central tolerance induction. Nature reviews. Immunology\| PubMed ID: 19935803	2009
Aire, master of many trades. Cell\| PubMed ID: 20085700	2010
Chronic inflammation is regarded as a strong promoter of tumorigenesis. International journal of cancer. Journal international du cancer\| PubMed ID: 20564540	2010
How thymic antigen presenting cells sample the body's self-antigens. Current opinion in immunology\| PubMed ID: 20832274	2010
Epigenetic regulation of promiscuous gene expression in thymic medullary epithelial cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20966351	2010
Jagged2 acts as a Delta-like Notch ligand during early hematopoietic cell fate decisions. Blood\| PubMed ID: 21372153	2011
Impaired thymic tolerance to α-myosin directs autoimmunity to the heart in mice and humans. The Journal of clinical investigation\| PubMed ID: 21436590	2011
Association of an SNP with intrathymic transcription of TSHR and Graves' disease: a role for defective thymic tolerance. Human molecular genetics\| PubMed ID: 21642385	2011
DNA methylation signatures of the AIRE promoter in thymic epithelial cells, thymomas and normal tissues. Molecular immunology\| PubMed ID: 22036612	2011
The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor. Nature immunology\| PubMed ID: 22179202	2012
The classical dichotomy between presentation of endogenous antigens via the MHC class I pathway and exogenous antigens via the MHC class-II pathway. Current opinion in immunology\| PubMed ID: 22305303	2012
An organotypic coculture model supporting proliferation and differentiation of medullary thymic epithelial cells and promiscuous gene expression. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 23269248	2013
An evolutionarily conserved mutual interdependence between Aire and microRNAs in promiscuous gene expression. European journal of immunology\| PubMed ID: 23589212	2013
Overlapping gene coexpression patterns in human medullary thymic epithelial cells generate self-antigen diversity. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23980163	2013
Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see). Nature reviews. Immunology\| PubMed ID: 24830344	2014
Misinitiation of intrathymic MART-1 transcription and biased TCR usage explain the high frequency of MART-1-specific T cells. European journal of immunology\| PubMed ID: 24846220	2014
Adult thymus contains FoxN1(-) epithelial stem cells that are bipotent for medullary and cortical thymic epithelial lineages. Immunity\| PubMed ID: 25148026	2014
Love is in the Aire: mTECs share their assets. Immunity\| PubMed ID: 25238088	2014
Homeodomain-interacting protein kinase 2, a novel autoimmune regulator interaction partner, modulates promiscuous gene expression in medullary thymic epithelial cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 25552543	2015
Central T cell tolerance: Identification of tissue-restricted autoantigens in the thymus HLA-DR peptidome. Journal of autoimmunity\| PubMed ID: 25911201	2015
Materno-fetal transfer of preproinsulin through the neonatal Fc receptor prevents autoimmune diabetes. Diabetes\| PubMed ID: 25918233	2015
Thymic B Cells Are Licensed to Present Self Antigens for Central T Cell Tolerance Induction. Immunity\| PubMed ID: 26070482	2015