Suzanne A. Eccles

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 217	2015

Other Publications

Article	Year
Parallels in invasion and angiogenesis provide pivotal points for therapeutic intervention. The International journal of developmental biology\| PubMed ID: 15349833	2004
The role of c-erbB receptors and ligands in head and neck squamous cell carcinoma. Oral oncology\| PubMed ID: 12167415	2002
Use of plasma MMP-2 and MMP-9 levels as a surrogate for tumour expression in colorectal cancer patients. International journal of cancer. Journal international du cancer\| PubMed ID: 14520690	2003
Phosphoinositide 3-kinase signalling pathways in tumor progression, invasion and angiogenesis. Tumori\| PubMed ID: 15143962	2004
Signaling pathways required for matrix metalloproteinase-9 induction by betacellulin in head-and-neck squamous carcinoma cells. International journal of cancer. Journal international du cancer\| PubMed ID: 15197768	2004
Combination epidermal growth factor receptor inhibition and radical radiotherapy for NSCLC. Expert review of anticancer therapy\| PubMed ID: 15270661	2004
Targeting key steps in metastatic tumour progression. Current opinion in genetics & development\| PubMed ID: 15661537	2005
Breast cancer metastasis: when, where, how? Lancet\| PubMed ID: 15781080	2005
Biological significance of c-erbB family oncogenes in head and neck cancer. Cancer metastasis reviews\| PubMed ID: 15785872	2005
PLCgamma1 is essential for early events in integrin signalling required for cell motility. Journal of cell science\| PubMed ID: 15944397	2005
The phosphoinositide 3-kinase signalling pathway as a therapeutic target in squamous cell carcinoma of the head and neck. Expert opinion on therapeutic targets\| PubMed ID: 16083342	2005
Cell migration/invasion assays and their application in cancer drug discovery. Biotechnology annual review\| PubMed ID: 16216785	2005
Identification of magnetic resonance detectable metabolic changes associated with inhibition of phosphoinositide 3-kinase signaling in human breast cancer cells. Molecular cancer therapeutics\| PubMed ID: 16432178	2006
Benzoquinone ansamycin heat shock protein 90 inhibitors modulate multiple functions required for tumor angiogenesis. Molecular cancer therapeutics\| PubMed ID: 16546966	2006
The vascular targeting property of paclitaxel is enhanced by SU6668, a receptor tyrosine kinase inhibitor, causing apoptosis of endothelial cells and inhibition of angiogenesis. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 16551869	2006
The phosphoinositide-specific phospholipase C inhibitor U73122 (1-(6-((17beta-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione) spontaneously forms conjugates with comm... Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 17403917	2007
Metastasis: recent discoveries and novel treatment strategies. Lancet\| PubMed ID: 17512859	2007
Application of meso scale technology for the measurement of phosphoproteins in human tumor xenografts. Assay and drug development technologies\| PubMed ID: 17638539	2007
4,5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer. Journal of medicinal chemistry\| PubMed ID: 18020435	2008
Plexin-B1 mutations in prostate cancer. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18024597	2007
AACR-NCI-EORTC--19th symposium. Molecular Targets and Cancer Therapeutics--Part 4. IDrugs : the investigational drugs journal\| PubMed ID: 18041676	2007
The Bcl-2/Bcl-XL family inhibitor ABT-737 sensitizes ovarian cancer cells to carboplatin. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 18056200	2007
An in vitro and in vivo study of the combination of the heat shock protein inhibitor 17-allylamino-17-demethoxygeldanamycin and carboplatin in human ovarian cancer models. Cancer chemotherapy and pharmacology\| PubMed ID: 18193424	2008
NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis. Cancer research\| PubMed ID: 18413753	2008
CHR-2797: an antiproliferative aminopeptidase inhibitor that leads to amino acid deprivation in human leukemic cells. Cancer research\| PubMed ID: 18701491	2008
The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor... Journal of medicinal chemistry\| PubMed ID: 18754654	2008
A microRNA DNA methylation signature for human cancer metastasis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18768788	2008
Molecular pharmacology of phosphatidylinositol 3-kinase inhibition in human glioma. Cell cycle (Georgetown, Tex.)\| PubMed ID: 19177002	2009
Determinants of response to epidermal growth factor receptor tyrosine kinase inhibition in squamous cell carcinoma of the head and neck. The Journal of pathology\| PubMed ID: 19197951	2009
In vitro assays for endothelial cell functions related to angiogenesis: proliferation, motility, tubular differentiation, and proteolysis. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 19301670	2009
The identification of novel PLC-gamma inhibitors using virtual high throughput screening. Bioorganic & medicinal chemistry\| PubMed ID: 19303309	2009
Changes in choline metabolism as potential biomarkers of phospholipase C{gamma}1 inhibition in human prostate cancer cells. Molecular cancer therapeutics\| PubMed ID: 19417158	2009
Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941. Molecular cancer therapeutics\| PubMed ID: 19584227	2009
Combining hit identification strategies: fragment-based and in silico approaches to orally active 2-aminothieno[2,3-d]pyrimidine inhibitors of the Hsp90 molecular chaperone. Journal of medicinal chemistry\| PubMed ID: 19610616	2009
Brk protects breast cancer cells from autophagic cell death induced by loss of anchorage. The American journal of pathology\| PubMed ID: 19661439	2009
The preclinical pharmacology and therapeutic activity of the novel CHK1 inhibitor SAR-020106. Molecular cancer therapeutics\| PubMed ID: 20053762	2010
Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt). Journal of medicinal chemistry\| PubMed ID: 20151677	2010
Mechanistic evaluation of the novel HSP90 inhibitor NVP-AUY922 in adult and pediatric glioblastoma. Molecular cancer therapeutics\| PubMed ID: 20457619	2010
Imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases: lead optimization studies toward the identification of an orally bioavailable preclinical development candidate. Journal of medicinal chemistry\| PubMed ID: 20565112	2010
Tumour-microenvironmental interactions: paths to progression and targets for treatment. Seminars in cancer biology\| PubMed ID: 20599506	2010
Bayesian estimation of changes in transverse relaxation rates. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine\| PubMed ID: 20806382	2010
Metastasis and the Tumor Microenvironment: A Joint Metastasis Research Society-AACR Conference - Research on Metastasis: Part 1. IDrugs : the investigational drugs journal\| PubMed ID: 21046522	2010
Metastasis and the Tumor Microenvironment: A Joint Metastasis Research Society-AACR Conference - Research on Metastasis: part 2. IDrugs : the investigational drugs journal\| PubMed ID: 21046523	2010
Preclinical pharmacology, antitumor activity, and development of pharmacodynamic markers for the novel, potent AKT inhibitor CCT128930. Molecular cancer therapeutics\| PubMed ID: 21191045	2011
Angiogenic functions of voltage-gated Na+ Channels in human endothelial cells: modulation of vascular endothelial growth factor (VEGF) signaling. The Journal of biological chemistry\| PubMed ID: 21385874	2011
Non-invasive in vivo imaging of vessel calibre in orthotopic prostate tumour xenografts. International journal of cancer. Journal international du cancer\| PubMed ID: 21469141	2012
Enhanced efficacy of IGF1R inhibition in pediatric glioblastoma by combinatorial targeting of PDGFRα/β. Molecular cancer therapeutics\| PubMed ID: 21659463	2011
Simple experimental and spontaneous metastasis assays in mice. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 21748685	2011
Ca2+ influx through reverse mode Na+/Ca2+ exchange is critical for vascular endothelial growth factor-mediated extracellular signal-regulated kinase (ERK) 1/2 activation and angiogenic funct... The Journal of biological chemistry\| PubMed ID: 21873429	2011
The aurora kinase inhibitor CCT137690 downregulates MYCN and sensitizes MYCN-amplified neuroblastoma in vivo. Molecular cancer therapeutics\| PubMed ID: 21885865	2011
Quantitative chemical proteomics reveals new potential drug targets in head and neck cancer. Molecular & cellular proteomics : MCP\| PubMed ID: 21955398	2011
Structure-guided evolution of potent and selective CHK1 inhibitors through scaffold morphing. Journal of medicinal chemistry\| PubMed ID: 22111927	2011
The epidermal growth factor receptor/Erb-B/HER family in normal and malignant breast biology. The International journal of developmental biology\| PubMed ID: 22161825	2011
Flexible targeting of ErbB dimers that drive tumorigenesis by using genetically engineered T cells. Molecular medicine (Cambridge, Mass.)\| PubMed ID: 22354215	2012
Epigenetic disruption of cadherin-11 in human cancer metastasis. The Journal of pathology\| PubMed ID: 22374749	2012
Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation and drug evaluation. BMC biology\| PubMed ID: 22439642	2012
The HSP90 inhibitor NVP-AUY922 radiosensitizes by abrogation of homologous recombination resulting in mitotic entry with unresolved DNA damage. PloS one\| PubMed ID: 22523597	2012
Dual targeting of ErbB2 and MUC1 in breast cancer using chimeric antigen receptors engineered to provide complementary signaling. Journal of clinical immunology\| PubMed ID: 22526592	2012
Dependence of Wilms tumor cells on signaling through insulin-like growth factor 1 in an orthotopic xenograft model targetable by specific receptor inhibition. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22529373	2012
Preclinical drug development for childhood cancer. Expert opinion on drug discovery\| PubMed ID: 22646826	2011
Kurt Hellmann D.M., D.Phil. Oxon. A happy 90th birthday! Clinical & experimental metastasis\| PubMed ID: 22695808	2012
AT13148 is a novel, oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 22781553	2012
The ALK(F1174L) mutation potentiates the oncogenic activity of MYCN in neuroblastoma. Cancer cell\| PubMed ID: 22789543	2012
Erratum to: Kurt Hellmann D.M., D.Phil. Oxon. A happy 90th birthday! Clinical & experimental metastasis\| PubMed ID: 22872374	2012
CCT244747 is a novel potent and selective CHK1 inhibitor with oral efficacy alone and in combination with genotoxic anticancer drugs. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 22929806	2012
Optimization of imidazo[4,5-b]pyridine-based kinase inhibitors: identification of a dual FLT3/Aurora kinase inhibitor as an orally bioavailable preclinical development candidate for the trea... Journal of medicinal chemistry\| PubMed ID: 23043539	2012
Discovery of 3-alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitriles as selective, orally bioavailable CHK1 inhibitors. Journal of medicinal chemistry\| PubMed ID: 23082860	2012
Two-dimensional vs. three-dimensional in vitro tumor migration and invasion assays. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 23436416	2013
Tumor spheroid-based migration assays for evaluation of therapeutic agents. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 23436417	2013
A novel serum protein signature associated with resistance to epidermal growth factor receptor tyrosine kinase inhibitors in head and neck squamous cell carcinoma. European journal of cancer (Oxford, England : 1990)\| PubMed ID: 23582742	2013
A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells. Journal of the American Chemical Society\| PubMed ID: 23796364	2013
Kurt Hellmann D. M., D. Phil. Oxon 1922–2013. Clinical & experimental metastasis\| PubMed ID: 23844428	2013
Dual blockade of the PI3K/AKT/mTOR (AZD8055) and RAS/MEK/ERK (AZD6244) pathways synergistically inhibits rhabdomyosarcoma cell growth in vitro and in vivo. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 23918606	2013
Mode of cell death induced by the HSP90 inhibitor 17-AAG (tanespimycin) is dependent on the expression of pro-apoptotic BAX. Oncotarget\| PubMed ID: 24185264	2013
Structure-based design of orally bioavailable 1H-pyrrolo[3,2-c]pyridine inhibitors of mitotic kinase monopolar spindle 1 (MPS1). Journal of medicinal chemistry\| PubMed ID: 24256217	2013
Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer. Breast cancer research : BCR\| PubMed ID: 24286369	2013
Preclinical evaluation of imaging biomarkers for prostate cancer bone metastasis and response to cabozantinib. Journal of the National Cancer Institute\| PubMed ID: 24634505	2014
HIF-1α-independent hypoxia-induced rapid PTK6 stabilization is associated with increased motility and invasion. Cancer biology & therapy\| PubMed ID: 25019382	2014
An open letter to the FDA and other regulatory agencies: Preclinical drug development must consider the impact on metastasis. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 25278743	2009
Cancer-associated fibroblasts induce high mobility group box 1 and contribute to resistance to doxorubicin in breast cancer cells. BMC cancer\| PubMed ID: 25512109	2014
Exploring the biomechanical properties of brain malignancies and their pathologic determinants in vivo with magnetic resonance elastography. Cancer research\| PubMed ID: 25672978	2015
Discovery of potent, orally bioavailable, small-molecule inhibitors of WNT signaling from a cell-based pathway screen. Journal of medicinal chemistry\| PubMed ID: 25680029	2015