Michael E. Himmel

Affiliated with

Research Area

Biography

Michael E. Himmel has not added Biography.
If you are Michael E. Himmel and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 19	2015

Other Publications

Article	Year
Exploration of cellulose surface-binding properties of acidothermus cellulolyticus Cel5A by site-specific mutagenesis. Applied biochemistry and biotechnology\| PubMed ID: 12018255	2002
Effect of single active-site cleft mutation on product specificity in a thermostable bacterial cellulase. Applied biochemistry and biotechnology\| PubMed ID: 12018266	2002
Automated filter paper assay for determination of cellulase activity. Applied biochemistry and biotechnology\| PubMed ID: 12721448	2003
The bacterial scaffoldin: structure, function and potential applications in the nanosciences. Genetic engineering\| PubMed ID: 15260240	2003
Direct imaging of surface-enhanced Raman scattering in the near field. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 15641817	2005
Catalytically enhanced endocellulase Cel5A from Acidothermus cellulolyticus. Applied biochemistry and biotechnology\| PubMed ID: 15917594	2005
Acidic sugar degradation pathways: an ab initio molecular dynamics study. Applied biochemistry and biotechnology\| PubMed ID: 15930576	2005
Electrochemical oxidation of water by a cellobiose dehydrogenase from Phanerochaete chrysosporium. Biotechnology letters\| PubMed ID: 15973489	2005
Ab initio molecular dynamics simulations of beta-D-glucose and beta-D-xylose degradation mechanisms in acidic aqueous solution. Carbohydrate research\| PubMed ID: 16095579	2005
Self-assembly of photoactive TiO2-cyclodextrin wires. Journal of the American Chemical Society\| PubMed ID: 16248603	2005
Beta-D-glucosidase reaction kinetics from isothermal titration microcalorimetry. Analytical biochemistry\| PubMed ID: 16269126	2005
Computer simulation studies of microcrystalline cellulose Ibeta. Carbohydrate research\| PubMed ID: 16297893	2006
The maize primary cell wall microfibril: a new model derived from direct visualization. Journal of agricultural and food chemistry\| PubMed ID: 16448156	2006
Determination of lignin by size exclusion chromatography using multi angle laser light scattering. Journal of chromatography. A\| PubMed ID: 16566937	2006
Mechanisms of glycerol dehydration. The journal of physical chemistry. A\| PubMed ID: 16671686	2006
Outlook for cellulase improvement: screening and selection strategies. Biotechnology advances\| PubMed ID: 16690241	2006
Catalyst transport in corn stover internodes: elucidating transport mechanisms using Direct Blue-I. Applied biochemistry and biotechnology\| PubMed ID: 16915666	2006
Energetics of xylose decomposition as determined using quantum mechanics modeling. The journal of physical chemistry. A\| PubMed ID: 17048814	2006
Versatile derivatives of carbohydrate-binding modules for imaging of complex carbohydrates approaching the molecular level of resolution. BioTechniques\| PubMed ID: 17068959	2006
Expression and characterization of Acidothermus cellulolyticus E1 endoglucanase in transgenic duckweed Lemna minor 8627. Bioresource technology\| PubMed ID: 17127051	2007
Biomass recalcitrance: engineering plants and enzymes for biofuels production. Science (New York, N.Y.)\| PubMed ID: 17289988	2007
Fractionating recalcitrant lignocellulose at modest reaction conditions. Biotechnology and bioengineering\| PubMed ID: 17318910	2007
Cellulase digestibility of pretreated biomass is limited by cellulose accessibility. Biotechnology and bioengineering\| PubMed ID: 17335064	2007
Microscopic analysis of corn fiber using starch- and cellulose-specific molecular probes. Biotechnology and bioengineering\| PubMed ID: 17335065	2007
Molecular modeling suggests induced fit of Family I carbohydrate-binding modules with a broken-chain cellulose surface. Protein engineering, design & selection : PEDS\| PubMed ID: 17430975	2007
The potential of cellulases and cellulosomes for cellulosic waste management. Current opinion in biotechnology\| PubMed ID: 17462879	2007
Deposition of lignin droplets produced during dilute acid pretreatment of maize stems retards enzymatic hydrolysis of cellulose. Biotechnology progress\| PubMed ID: 17973399	2007
Synergistic enhancement of cellobiohydrolase performance on pretreated corn stover by addition of xylanase and esterase activities. Bioresource technology\| PubMed ID: 18006303	2008
Heterologous expression of Aspergillus niger beta-D-xylosidase (XlnD): characterization on lignocellulosic substrates. Applied biochemistry and biotechnology\| PubMed ID: 18421587	2008
Heterologous expression of two ferulic acid esterases from Penicillium funiculosum. Applied biochemistry and biotechnology\| PubMed ID: 18421589	2008
Implications of cellobiohydrolase glycosylation for use in biomass conversion. Biotechnology for biofuels\| PubMed ID: 18471276	2008
Welcome to biotechnology for biofuels. Biotechnology for biofuels\| PubMed ID: 18471312	2008
A biophysical perspective on the cellulosome: new opportunities for biomass conversion. Current opinion in biotechnology\| PubMed ID: 18513939	2008
Heterologous expression of glycosyl hydrolases in planta: a new departure for biofuels. Trends in biotechnology\| PubMed ID: 18579242	2008
Visualizing lignin coalescence and migration through maize cell walls following thermochemical pretreatment. Biotechnology and bioengineering\| PubMed ID: 18781690	2008
Redistribution of xylan in maize cell walls during dilute acid pretreatment. Biotechnology and bioengineering\| PubMed ID: 19161247	2009
Engineered carbohydrate-binding module (CBM) protein-suspended single-walled carbon nanotubes in water. Chemical communications (Cambridge, England)\| PubMed ID: 19209321	2009
The effect of lignin removal by alkaline peroxide pretreatment on the susceptibility of corn stover to purified cellulolytic and xylanolytic enzymes. Applied biochemistry and biotechnology\| PubMed ID: 19214798	2009
Detecting cellulase penetration into corn stover cell walls by immuno-electron microscopy. Biotechnology and bioengineering\| PubMed ID: 19266575	2009
Perspectives and new directions for the production of bioethanol using consolidated bioprocessing of lignocellulose. Current opinion in biotechnology\| PubMed ID: 19520566	2009
Lignocellulose conversion to biofuels: current challenges, global perspectives. Current opinion in biotechnology\| PubMed ID: 19523813	2009
The effects of water on beta-D-xylose condensation reactions. The journal of physical chemistry. A\| PubMed ID: 19572686	2009
The energy landscape for the interaction of the family 1 carbohydrate-binding module and the cellulose surface is altered by hydrolyzed glycosidic bonds. The journal of physical chemistry. B\| PubMed ID: 19594145	2009
Computational simulations of the Trichoderma reesei cellobiohydrolase I acting on microcrystalline cellulose Ibeta: the enzyme-substrate complex. Carbohydrate research\| PubMed ID: 19699474	2009
Plant cell wall characterization using scanning probe microscopy techniques. Biotechnology for biofuels\| PubMed ID: 19703302	2009
Identification of amino acids responsible for processivity in a Family 1 carbohydrate-binding module from a fungal cellulase. The journal of physical chemistry. B\| PubMed ID: 20050714	2010
Glucose reversion reaction kinetics. Journal of agricultural and food chemistry\| PubMed ID: 20429509	2010
Cellulose crystallinity index: measurement techniques and their impact on interpreting cellulase performance. Biotechnology for biofuels\| PubMed ID: 20497524	2010
Label-free, real-time monitoring of biomass processing with stimulated Raman scattering microscopy. Angewandte Chemie (International ed. in English)\| PubMed ID: 20589818	2010
The unique binding mode of cellulosomal CBM4 from Clostridium thermocellum cellobiohydrolase A. Journal of molecular biology\| PubMed ID: 20654622	2010
The role of hydrogen-bonding interactions in acidic sugar reaction pathways. Carbohydrate research\| PubMed ID: 20667524	2010
Structure of a fibronectin type III-like module from Clostridium thermocellum. Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 20693658	2010
Simulation studies of the insolubility of cellulose. Carbohydrate research\| PubMed ID: 20705283	2010
Antisense down-regulation of 4CL expression alters lignification, tree growth, and saccharification potential of field-grown poplar. Plant physiology\| PubMed ID: 20729393	2010
Sequencing of multiple clostridial genomes related to biomass conversion and biofuel production. Journal of bacteriology\| PubMed ID: 20889752	2010
Free energy landscape for glucose condensation reactions. The journal of physical chemistry. A\| PubMed ID: 21086968	2010
Modeling the self-assembly of the cellulosome enzyme complex. The Journal of biological chemistry\| PubMed ID: 21098021	2011
The O-glycosylated linker from the Trichoderma reesei Family 7 cellulase is a flexible, disordered protein. Biophysical journal\| PubMed ID: 21112302	2010
In situ imaging of single carbohydrate-binding modules on cellulose microfibrils. The journal of physical chemistry. B\| PubMed ID: 21162585	2011
Applications of computational science for understanding enzymatic deconstruction of cellulose. Current opinion in biotechnology\| PubMed ID: 21168322	2011
In planta expression of A. cellulolyticus Cel5A endocellulase reduces cell wall recalcitrance in tobacco and maize. Biotechnology for biofuels\| PubMed ID: 21269444	2011
Cellobiohydrolase hydrolyzes crystalline cellulose on hydrophobic faces. The Journal of biological chemistry\| PubMed ID: 21282110	2011
High throughput determination of glucan and xylan fractions in lignocelluloses. Biotechnology letters\| PubMed ID: 21287235	2011
High-temperature behavior of cellulose I. The journal of physical chemistry. B\| PubMed ID: 21338135	2011
Sugar-binding sites on the surface of the carbohydrate-binding module of CBH I from Trichoderma reesei. Carbohydrate research\| PubMed ID: 21377658	2011
Molecular-level origins of biomass recalcitrance: decrystallization free energies for four common cellulose polymorphs. The journal of physical chemistry. B\| PubMed ID: 21425804	2011
Probing carbohydrate product expulsion from a processive cellulase with multiple absolute binding free energy methods. The Journal of biological chemistry\| PubMed ID: 21454590	2011
Structure of CBM4 from Clostridium thermocellum cellulase K. Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 21543854	2011
Bioprospecting metagenomics of decaying wood: mining for new glycoside hydrolases. Biotechnology for biofuels\| PubMed ID: 21816041	2011
Protein allostery at the solid-liquid interface: endoglucanase attachment to cellulose affects glucan clenching in the binding cleft. Journal of the American Chemical Society\| PubMed ID: 21877736	2011
Multiple functions of aromatic-carbohydrate interactions in a processive cellulase examined with molecular simulation. The Journal of biological chemistry\| PubMed ID: 21965672	2011
Effects of alkaline or liquid-ammonia treatment on crystalline cellulose: changes in crystalline structure and effects on enzymatic digestibility. Biotechnology for biofuels\| PubMed ID: 22011342	2011
Elucidating the role of ferrous ion cocatalyst in enhancing dilute acid pretreatment of lignocellulosic biomass. Biotechnology for biofuels\| PubMed ID: 22074910	2011
Weakly hydrated surfaces and the binding interactions of small biological solutes. European biophysics journal : EBJ\| PubMed ID: 22124617	2012
A 1.5 Å resolution X-ray structure of the catalytic module of Caldicellulosiruptor bescii family 3 pectate lyase. Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 22139151	2011
Computational investigation of glycosylation effects on a family 1 carbohydrate-binding module. The Journal of biological chemistry\| PubMed ID: 22147693	2012
Harnessing glycosylation to improve cellulase activity. Current opinion in biotechnology\| PubMed ID: 22186222	2012
Molecular dynamics simulations of the interaction of glucose with imidazole in aqueous solution. Carbohydrate research\| PubMed ID: 22248861	2012
Structure and function of the Clostridium thermocellum cellobiohydrolase A X1-module repeat: enhancement through stabilization of the CbhA complex. Acta crystallographica. Section D, Biological crystallography\| PubMed ID: 22349231	2012
Deconstruction of lignocellulosic biomass to fuels and chemicals. Annual review of chemical and biomolecular engineering\| PubMed ID: 22432613	2011
Tracking dynamics of plant biomass composting by changes in substrate structure, microbial community, and enzyme activity. Biotechnology for biofuels\| PubMed ID: 22490508	2012
Binding preferences, surface attachment, diffusivity, and orientation of a family 1 carbohydrate-binding module on cellulose. The Journal of biological chemistry\| PubMed ID: 22496371	2012
The metagenome of an anaerobic microbial community decomposing poplar wood chips. PloS one\| PubMed ID: 22629327	2012
Product binding varies dramatically between processive and nonprocessive cellulase enzymes. The Journal of biological chemistry\| PubMed ID: 22648408	2012
Challenges for assessing the performance of biomass degrading biocatalysts. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 22843384	2012
Coherent Raman microscopy analysis of plant cell walls. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 22843388	2012
Single-molecule tracking of carbohydrate-binding modules on cellulose using fluorescence microscopy. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 22843396	2012
Analysis of transgenic glycoside hydrolases expressed in plants: T. reesei CBH I and A. cellulolyticus EI. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 22843401	2012
Improved ethanol yield and reduced Minimum Ethanol Selling Price (MESP) by modifying low severity dilute acid pretreatment with deacetylation and mechanical refining: 1) Experimental. Biotechnology for biofuels\| PubMed ID: 22888758	2012
Considering water availability and the effect of solute concentration on high solids saccharification of lignocellulosic biomass. Biotechnology progress\| PubMed ID: 22915470	2012
Improved ethanol yield and reduced minimum ethanol selling price (MESP) by modifying low severity dilute acid pretreatment with deacetylation and mechanical refining: 2) Techno-economic anal... Biotechnology for biofuels\| PubMed ID: 22967479	2012
Sequence, structure, and evolution of cellulases in glycoside hydrolase family 48. The Journal of biological chemistry\| PubMed ID: 23055526	2012
Paradigmatic status of an endo- and exoglucanase and its effect on crystalline cellulose degradation. Biotechnology for biofuels\| PubMed ID: 23095278	2012
Cellulase linkers are optimized based on domain type and function: insights from sequence analysis, biophysical measurements, and molecular simulation. PloS one\| PubMed ID: 23139804	2012
How does plant cell wall nanoscale architecture correlate with enzymatic digestibility? Science (New York, N.Y.)\| PubMed ID: 23180856	2012
Computational investigation of the pH dependence of loop flexibility and catalytic function in glycoside hydrolases. The Journal of biological chemistry\| PubMed ID: 23504310	2013
The structure and mode of action of Caldicellulosiruptor bescii family 3 pectate lyase in biomass deconstruction. Acta crystallographica. Section D, Biological crystallography\| PubMed ID: 23519661	2013
Crystal structure and computational characterization of the lytic polysaccharide monooxygenase GH61D from the Basidiomycota fungus Phanerochaete chrysosporium. The Journal of biological chemistry\| PubMed ID: 23525113	2013
Binding site dynamics and aromatic-carbohydrate interactions in processive and non-processive family 7 glycoside hydrolases. The journal of physical chemistry. B\| PubMed ID: 23534900	2013
Structural characterization of a unique marine animal family 7 cellobiohydrolase suggests a mechanism of cellulase salt tolerance. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23733951	2013
Hydration and saccharification of cellulose Iβ, II and III(I) at increasing dry solids loadings. Biotechnology letters\| PubMed ID: 23881312	2013
Glycosylated linkers in multimodular lignocellulose-degrading enzymes dynamically bind to cellulose. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23959893	2013
Endoglucanase peripheral loops facilitate complexation of glucan chains on cellulose via adaptive coupling to the emergent substrate structures. The journal of physical chemistry. B\| PubMed ID: 23972069	2013
Improving activity of minicellulosomes by integration of intra- and intermolecular synergies. Biotechnology for biofuels\| PubMed ID: 23987588	2013
3D electron tomography of pretreated biomass informs atomic modeling of cellulose microfibrils. ACS nano\| PubMed ID: 23988022	2013
Genomic, proteomic, and biochemical analyses of oleaginous Mucor circinelloides: evaluating its capability in utilizing cellulolytic substrates for lipid production. PloS one\| PubMed ID: 24023719	2013
Impact of alg3 gene deletion on growth, development, pigment production, protein secretion, and functions of recombinant Trichoderma reesei cellobiohydrolases in Aspergillus niger. Fungal genetics and biology : FG & B\| PubMed ID: 24076077	2013
Cel48A from Thermobifida fusca: structure and site directed mutagenesis of key residues. Biotechnology and bioengineering\| PubMed ID: 24264519	2014
Glycoside hydrolase processivity is directly related to oligosaccharide binding free energy. Journal of the American Chemical Society\| PubMed ID: 24279927	2013
Structure of Acidothermus cellulolyticus family 74 glycoside hydrolase at 1.82 Å resolution. Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 24316824	2013
Revealing nature's cellulase diversity: the digestion mechanism of Caldicellulosiruptor bescii CelA. Science (New York, N.Y.)\| PubMed ID: 24357319	2013
The complete mitochondrial genome of Limnoria quadripunctata Holthuis (Isopoda: Limnoriidae). Mitochondrial DNA\| PubMed ID: 24409843	2014
Multiscale deconstruction of molecular architecture in corn stover. Scientific reports\| PubMed ID: 24441444	2014
Experimental and modeling studies of an unusual water-filled pore structure with possible mechanistic implications in family 48 cellulases. The journal of physical chemistry. B\| PubMed ID: 24471470	2014
Charge engineering of cellulases improves ionic liquid tolerance and reduces lignin inhibition. Biotechnology and bioengineering\| PubMed ID: 24522957	2014
Effect of mechanical disruption on the effectiveness of three reactors used for dilute acid pretreatment of corn stover Part 2: morphological and structural substrate analysis. Biotechnology for biofuels\| PubMed ID: 24690534	2014
Agave proves to be a low recalcitrant lignocellulosic feedstock for biofuels production on semi-arid lands. Biotechnology for biofuels\| PubMed ID: 24708685	2014
Effect of mechanical disruption on the effectiveness of three reactors used for dilute acid pretreatment of corn stover Part 1: chemical and physical substrate analysis. Biotechnology for biofuels\| PubMed ID: 24713111	2014
Comparison of transcriptional profiles of Clostridium thermocellum grown on cellobiose and pretreated yellow poplar using RNA-Seq. Frontiers in microbiology\| PubMed ID: 24782837	2014
Response to Comment on "Revealing nature's cellulase diversity: the digestion mechanism of Caldicellulosiruptor bescii CelA". Science (New York, N.Y.)\| PubMed ID: 24812382	2014
Specificity of O-glycosylation in enhancing the stability and cellulose binding affinity of Family 1 carbohydrate-binding modules. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24821760	2014
Towards a molecular-level theory of carbohydrate processivity in glycoside hydrolases. Current opinion in biotechnology\| PubMed ID: 24863902	2014
Carbohydrate-protein interactions that drive processive polysaccharide translocation in enzymes revealed from a computational study of cellobiohydrolase processivity. Journal of the American Chemical Society\| PubMed ID: 24869982	2014
Predicting enzyme adsorption to lignin films by calculating enzyme surface hydrophobicity. The Journal of biological chemistry\| PubMed ID: 24876380	2014
The structure of the catalytic domain of a plant cellulose synthase and its assembly into dimers. The Plant cell\| PubMed ID: 25012190	2014
NIR and Py-mbms coupled with multivariate data analysis as a high-throughput biomass characterization technique: a review. Frontiers in plant science\| PubMed ID: 25147552	2014
Deletion of Caldicellulosiruptor bescii CelA reveals its crucial role in the deconstruction of lignocellulosic biomass. Biotechnology for biofuels\| PubMed ID: 25317205	2014
Engineering towards a complete heterologous cellulase secretome in Yarrowia lipolytica reveals its potential for consolidated bioprocessing. Biotechnology for biofuels\| PubMed ID: 25337149	2014
Heterologous expression of xylanase enzymes in lipogenic yeast Yarrowia lipolytica. PloS one\| PubMed ID: 25462572	2014
Heterologous protein expression in Hypocrea jecorina: a historical perspective and new developments. Biotechnology advances\| PubMed ID: 25479282	2015
High temperature pre-digestion of corn stover biomass for improved product yields. Biotechnology for biofuels\| PubMed ID: 25489338	2014
Fungal cellulases. Chemical reviews\| PubMed ID: 25629559	2015
Discrete and structurally unique proteins (tāpirins) mediate attachment of extremely thermophilic Caldicellulosiruptor species to cellulose. The Journal of biological chemistry\| PubMed ID: 25720489	2015
Homologous expression of the Caldicellulosiruptor bescii CelA reveals that the extracellular protein is glycosylated. PloS one\| PubMed ID: 25799047	2015
Annual acknowledgement of manuscript reviewers. Biotechnology for biofuels\| PubMed ID: 25821517	2015
The molecular origins of twist in cellulose I-beta. Carbohydrate polymers\| PubMed ID: 25857969	2015
A constitutive expression system for glycosyl hydrolase family 7 cellobiohydrolases in Hypocrea jecorina. Biotechnology for biofuels\| PubMed ID: 25904982	2015
Cofactor Specificity of the Bifunctional Alcohol and Aldehyde Dehydrogenase (AdhE) in Wild-Type and Mutant Clostridium thermocellum and Thermoanaerobacterium saccharolyticum. Journal of bacteriology\| PubMed ID: 26013492	2015
Identifying the ionically bound cell wall and intracellular glycoside hydrolases in late growth stage Arabidopsis stems: implications for the genetic engineering of bioenergy crops. Frontiers in plant science\| PubMed ID: 26029221	2015
Expression of the Acidothermus cellulolyticus E1 endoglucanase in Caldicellulosiruptor bescii enhances its ability to deconstruct crystalline cellulose. Biotechnology for biofuels\| PubMed ID: 26269712	2015
In situ micro-spectroscopic investigation of lignin in poplar cell walls pretreated by maleic acid. Biotechnology for biofuels\| PubMed ID: 26312066	2015
The catalytic mechanism and unique low pH optimum of Caldicellulosiruptor bescii family 3 pectate lyase. Acta crystallographica. Section D, Biological crystallography\| PubMed ID: 26327384	2015