Hans Clevers

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JoVE Journal Publications

ArticleTotal : 6	Year
Publication title Cited by 144	2015
Publication title Cited by 121	2017
Publication title Cited by 2	2023
Publication title Cited by 15	2021
Publication title	2026

Other Publications

Article	Year
Cyclin D2-cyclin-dependent kinase 4/6 is required for efficient proliferation and tumorigenesis following Apc loss. Cancer research\| PubMed ID: 20736363	2010
Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells. Cell\| PubMed ID: 20887898	2010
Sumoylation by Ubc9 regulates the stem cell compartment and structure and function of the intestinal epithelium in mice. Gastroenterology\| PubMed ID: 20951138	2011
Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex. Developmental cell\| PubMed ID: 19386264	2009
OLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells. Gastroenterology\| PubMed ID: 19450592	2009
HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction. Nature neuroscience\| PubMed ID: 19503085	2009
The ets-domain transcription factor Spdef promotes maturation of goblet and paneth cells in the intestinal epithelium. Gastroenterology\| PubMed ID: 19549527	2009
LKB1 and AMPK family signaling: the intimate link between cell polarity and energy metabolism. Physiological reviews\| PubMed ID: 19584313	2009
Distinct gene mutation profiles among luminal-type and basal-type breast cancer cell lines. Breast cancer research and treatment\| PubMed ID: 19593635	2010
p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice. Nature genetics\| PubMed ID: 19718028	2009
A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial development. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19741146	2009
SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production. The Journal of clinical investigation\| PubMed ID: 19759516	2009
The kinase TNIK is an essential activator of Wnt target genes. The EMBO journal\| PubMed ID: 19816403	2009
Eyeing up new Wnt pathway players. Cell\| PubMed ID: 19837026	2009
Phosphatidylinositol 3-kinase signaling does not activate the wnt cascade. The Journal of biological chemistry\| PubMed ID: 19850932	2009
Fishing for intestinal cancer models: unraveling gastrointestinal homeostasis and tumorigenesis in zebrafish. Zebrafish\| PubMed ID: 19929219	2009
In situ hybridization to identify gut stem cells. Current protocols in stem cell biology\| PubMed ID: 20049690	2010
Searching for adult stem cells in the intestine. EMBO molecular medicine\| PubMed ID: 20049728	2009
Conversion of metaplastic Barrett's epithelium into post-mitotic goblet cells by gamma-secretase inhibition. Disease models & mechanisms\| PubMed ID: 20075383	2010
Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro. Cell stem cell\| PubMed ID: 20085740	2010
Coexistence of quiescent and active adult stem cells in mammals. Science (New York, N.Y.)\| PubMed ID: 20110496	2010
MAP3K1 functionally interacts with Axin1 in the canonical Wnt signalling pathway. Biological chemistry\| PubMed ID: 20128690	2010
Spindle orientation bias in gut epithelial stem cell compartments is lost in precancerous tissue. Cell stem cell\| PubMed ID: 20144789	2010
Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin. Science (New York, N.Y.)\| PubMed ID: 20223988	2010
Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl. Molecular cell\| PubMed ID: 20227366	2010
Active Wnt signaling in response to cardiac injury. Basic research in cardiology\| PubMed ID: 20373104	2010
Leucine-rich repeat-containing G-protein-coupled receptors as markers of adult stem cells. Gastroenterology\| PubMed ID: 20417836	2010
Lineage tracing in the intestinal epithelium. Current protocols in stem cell biology\| PubMed ID: 20443207	2010
Indian hedgehog regulates intestinal stem cell fate through epithelial-mesenchymal interactions during development. Gastroenterology\| PubMed ID: 20542037	2010
Wnts as self-renewal factors: mammary stem cells and beyond. Cell stem cell\| PubMed ID: 20569681	2010
Stem cells and cancer of the stomach and intestine. Molecular oncology\| PubMed ID: 20598659	2010
TCF4 and CDX2, major transcription factors for intestinal function, converge on the same cis-regulatory regions. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20696899	2010
Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling. Developmental cell\| PubMed ID: 20708588	2010
Intestinal stem cells lacking the Math1 tumour suppressor are refractory to Notch inhibitors. Nature communications\| PubMed ID: 20975679	2010
p21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epithelium. EMBO molecular medicine\| PubMed ID: 20976827	2010
The cytomegalovirus-encoded chemokine receptor US28 promotes intestinal neoplasia in transgenic mice. The Journal of clinical investigation\| PubMed ID: 20978345	2010
Chemoprevention by nonsteroidal anti-inflammatory drugs eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21041628	2010
The leukemia-associated Mllt10/Af10-Dot1l are Tcf4/β-catenin coactivators essential for intestinal homeostasis. PLoS biology\| PubMed ID: 21103407	2010
Tissue-resident adult stem cell populations of rapidly self-renewing organs. Cell stem cell\| PubMed ID: 21112561	2010
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Nature\| PubMed ID: 21113151	2011
Efficient double fragmentation ChIP-seq provides nucleotide resolution protein-DNA binding profiles. PloS one\| PubMed ID: 21152096	2010
Sox9 marks adult organ progenitors. Nature genetics\| PubMed ID: 21217637	2011
Tracking adult stem cells. EMBO reports\| PubMed ID: 21252944	2011
A comprehensive model of the spatio-temporal stem cell and tissue organisation in the intestinal crypt. PLoS computational biology\| PubMed ID: 21253562	2011
Lgr5 intestinal stem cells have high telomerase activity and randomly segregate their chromosomes. The EMBO journal\| PubMed ID: 21297579	2011
The serine-threonine kinase LKB1 is essential for survival under energetic stress in zebrafish. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21368212	2011
Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium. The Journal of cell biology\| PubMed ID: 21383077	2011
The cancer stem cell: premises, promises and challenges. Nature medicine\| PubMed ID: 21386835	2011
The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse. Cell stem cell\| PubMed ID: 21419747	2011
Differentiated human colorectal cancer cells protect tumor-initiating cells from irinotecan. Gastroenterology\| PubMed ID: 21459094	2011
Strategies for homeostatic stem cell self-renewal in adult tissues. Cell\| PubMed ID: 21663791	2011
Actomyosin-mediated cellular tension drives increased tissue stiffness and Î²-catenin activation to induce epidermal hyperplasia and tumor growth. Cancer cell\| PubMed ID: 21665151	2011
Highly sensitive proteome analysis of FACS-sorted adult colon stem cells. Journal of proteome research\| PubMed ID: 21696214	2011
Retinoic acid-induced pancreatic stellate cell quiescence reduces paracrine Wnt-β-catenin signaling to slow tumor progression. Gastroenterology\| PubMed ID: 21704588	2011
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling. Nature\| PubMed ID: 21727895	2011
Stem cell self-renewal in intestinal crypt. Experimental cell research\| PubMed ID: 21787769	2011
Slide preparation for single-cell-resolution imaging of fluorescent proteins in their three-dimensional near-native environment. Nature protocols\| PubMed ID: 21799490	2011
The BMP antagonist follistatin-like 1 is required for skeletal and lung organogenesis. PloS one\| PubMed ID: 21826198	2011
Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium. Gastroenterology\| PubMed ID: 21889923	2011
Isolation and in vitro expansion of human colonic stem cells. Nature medicine\| PubMed ID: 21892181	2011
Integrated genome-wide analysis of transcription factor occupancy, RNA polymerase II binding and steady-state RNA levels identify differentially regulated functional gene classes. Nucleic acids research\| PubMed ID: 21914722	2012
Single-cell dissection of transcriptional heterogeneity in human colon tumors. Nature biotechnology\| PubMed ID: 22081019	2011
Single-molecule transcript counting of stem-cell markers in the mouse intestine. Nature cell biology\| PubMed ID: 22119784	2012
Controlled gene expression in primary Lgr5 organoid cultures. Nature methods\| PubMed ID: 22138822	2012
Cdx2 determines the fate of postnatal intestinal endoderm. Development (Cambridge, England)\| PubMed ID: 22190642	2012
Method for estimating the single molecular affinity. Analytical biochemistry\| PubMed ID: 22209736	2012
Neural stem cells for diabetes cell-based therapy. EMBO molecular medicine\| PubMed ID: 22238783	2011
Optimality in the development of intestinal crypts. Cell\| PubMed ID: 22304925	2012
Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling. Nature cell biology\| PubMed ID: 22388892	2012
A critical role for the Wnt effector Tcf4 in adult intestinal homeostatic self-renewal. Molecular and cellular biology\| PubMed ID: 22393260	2012
What does the concept of the stem cell niche really mean today? BMC biology\| PubMed ID: 22405133	2012
Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5⁺ stem cell. Nature medicine\| PubMed ID: 22406745	2012
The R-spondin protein family. Genome biology\| PubMed ID: 22439850	2012
Wnt signaling, stem cells, and cancer of the gastrointestinal tract. Cold Spring Harbor perspectives in biology\| PubMed ID: 22474007	2012
Wnt/β-catenin and MAPK signaling: allies and enemies in different battlefields. Science signaling\| PubMed ID: 22494969	2012
In vitro expansion and transplantation of intestinal crypt stem cells. Gastroenterology\| PubMed ID: 22613623	2012
Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins. The EMBO journal\| PubMed ID: 22617424	2012
On the biomechanics of stem cell niche formation in the gut--modelling growing organoids. The FEBS journal\| PubMed ID: 22632461	2012
Wnt/β-catenin signaling and disease. Cell\| PubMed ID: 22682243	2012
Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex. Cell\| PubMed ID: 22682247	2012
The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers. The EMBO journal\| PubMed ID: 22692129	2012
Peyer's patch M cells derived from Lgr5(+) stem cells require SpiB and are induced by RankL in cultured "miniguts". Molecular and cellular biology\| PubMed ID: 22778137	2012
Rap2A links intestinal cell polarity to brush border formation. Nature cell biology\| PubMed ID: 22797597	2012
ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation. Nature\| PubMed ID: 22837003	2012
Crypt base columnar stem cells in small intestines of mice are radioresistant. Gastroenterology\| PubMed ID: 22841781	2012
Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas. Science (New York, N.Y.)\| PubMed ID: 22855427	2012
Chronic epithelial NF-κB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22893683	2012
Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors. Nature\| PubMed ID: 22895187	2012
Redundant sources of Wnt regulate intestinal stem cells and promote formation of Paneth cells. Gastroenterology\| PubMed ID: 22922422	2012
Cell biology. The unusual case of Porcupine. Science (New York, N.Y.)\| PubMed ID: 22923569	2012
Developmental stage-specific contribution of LGR5(+) cells to basal and luminal epithelial lineages in the postnatal mammary gland. The Journal of pathology\| PubMed ID: 22926799	2012
Modulating WNT receptor turnover for tissue repair. Nature biotechnology\| PubMed ID: 22965053	2012
Monoclonal antibodies against Lgr5 identify human colorectal cancer stem cells. Stem cells (Dayton, Ohio)\| PubMed ID: 22969042	2012
Lgr5(+ve) stem/progenitor cells contribute to nephron formation during kidney development. Cell reports\| PubMed ID: 22999937	2012
Dll1+ secretory progenitor cells revert to stem cells upon crypt damage. Nature cell biology\| PubMed ID: 23000963	2012
Identifying the stem cell of the intestinal crypt: strategies and pitfalls. Cell stem cell\| PubMed ID: 23040474	2012
The Paneth cell, caloric restriction, and intestinal integrity. The New England journal of medicine\| PubMed ID: 23075184	2012
Primary mouse small intestinal epithelial cell cultures. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 23097115	2013
Tales of the unexpected: Tcf1 functions as a tumor suppressor for leukemias. Immunity\| PubMed ID: 23159221	2012
The nuclear effector of Wnt-signaling, Tcf1, functions as a T-cell-specific tumor suppressor for development of lymphomas. PLoS biology\| PubMed ID: 23185135	2012
Identification of a clonally expanding haematopoietic compartment in bone marrow. The EMBO journal\| PubMed ID: 23188081	2013
Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand. Cell\| PubMed ID: 23260145	2012
Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties. Cell\| PubMed ID: 23273993	2013
Immunosurveillance against tetraploidization-induced colon tumorigenesis. Cell cycle (Georgetown, Tex.)\| PubMed ID: 23324343	2013
In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration. Nature\| PubMed ID: 23354049	2013
Intestinal regeneration: YAP-tumor suppressor and oncoprotein? Current biology : CB\| PubMed ID: 23391384	2013
Paneth cells: maestros of the small intestinal crypts. Annual review of physiology\| PubMed ID: 23398152	2013
Stem Cells: A unifying theory for the crypt. Nature\| PubMed ID: 23446347	2013
SnapShot: the intestinal crypt. Cell\| PubMed ID: 23452862	2013
Live imaging of astrocyte responses to acute injury reveals selective juxtavascular proliferation. Nature neuroscience\| PubMed ID: 23542688	2013
ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response. Cell reports\| PubMed ID: 23545496	2013
Conversion of mature human β-cells into glucagon-producing α-cells. Diabetes\| PubMed ID: 23569174	2013
A positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placenta. PLoS biology\| PubMed ID: 23610556	2013
Regulation of stem cell therapies under attack in Europe: for whom the bell tolls. The EMBO journal\| PubMed ID: 23644381	2013
Spdef null mice lack conjunctival goblet cells and provide a model of dry eye. The American journal of pathology\| PubMed ID: 23665202	2013
DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus. Genome biology\| PubMed ID: 23714178	2013
Lgr proteins in epithelial stem cell biology. Development (Cambridge, England)\| PubMed ID: 23715542	2013
A functional CFTR assay using primary cystic fibrosis intestinal organoids. Nature medicine\| PubMed ID: 23727931	2013
Growing self-organizing mini-guts from a single intestinal stem cell: mechanism and applications. Science (New York, N.Y.)\| PubMed ID: 23744940	2013
Structure of stem cell growth factor R-spondin 1 in complex with the ectodomain of its receptor LGR5. Cell reports\| PubMed ID: 23809763	2013
Lgr5(+) liver stem cells, hepatic organoids and regenerative medicine. Regenerative medicine\| PubMed ID: 23826690	2013
Concise review: the yin and yang of intestinal (cancer) stem cells and their progenitors. Stem cells (Dayton, Ohio)\| PubMed ID: 23836510	2013
Amplification of progenitors in the mammalian telencephalon includes a new radial glial cell type. Nature communications\| PubMed ID: 23839311	2013
The intestinal crypt, a prototype stem cell compartment. Cell\| PubMed ID: 23870119	2013
LGR4 expressed in uterine epithelium is necessary for uterine gland development and contributes to decidualization in mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 23975934	2013
Occult progression by Apc-deficient intestinal crypts as a target for chemoprevention. Carcinogenesis\| PubMed ID: 23996931	2014
Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis. The EMBO journal\| PubMed ID: 24045232	2013
A gutsy approach to stem cells and signalling: an interview with Hans Clevers. Disease models & mechanisms\| PubMed ID: 24046385	2013
Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium. Cell\| PubMed ID: 24120136	2013
Generation of L cells in mouse and human small intestine organoids. Diabetes\| PubMed ID: 24130334	2014
Retromer dependent recycling of the Wnt secretion factor Wls is dispensable for stem cell maintenance in the mammalian intestinal epithelium. PloS one\| PubMed ID: 24130821	2013
Generation of BAC transgenic epithelial organoids. PloS one\| PubMed ID: 24204693	2013
LGR5 positivity defines stem-like cells in colorectal cancer. Carcinogenesis\| PubMed ID: 24282287	2014
Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny. Nature methods\| PubMed ID: 24292484	2014
TTC7A mutations disrupt intestinal epithelial apicobasal polarity. The Journal of clinical investigation\| PubMed ID: 24292712	2014
Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients. Cell stem cell\| PubMed ID: 24315439	2013
Many inflammatory bowel disease risk loci include regions that regulate gene expression in immune cells and the intestinal epithelium. Gastroenterology\| PubMed ID: 24333384	2014
Structures of Wnt-antagonist ZNRF3 and its complex with R-spondin 1 and implications for signaling. PloS one\| PubMed ID: 24349440	2013
Biased competition between Lgr5 intestinal stem cells driven by oncogenic mutation induces clonal expansion. EMBO reports\| PubMed ID: 24355609	2014
Wnt-induced transcriptional activation is exclusively mediated by TCF/LEF. The EMBO journal\| PubMed ID: 24413017	2014
Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development. Nature\| PubMed ID: 24463518	2014
Ovarian LGR5 is critical for successful pregnancy. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 24469993	2014
Adult stem cells in the small intestine are intrinsically programmed with their location-specific function. Stem cells (Dayton, Ohio)\| PubMed ID: 24496776	2014
Retroviral gene expression control in primary organoid cultures. Current protocols in stem cell biology\| PubMed ID: 24510288	2013
Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging. Nature\| PubMed ID: 24531760	2014
The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength. Genes & development\| PubMed ID: 24532711	2014
STRAD pseudokinases regulate axogenesis and LKB1 stability. Neural development\| PubMed ID: 24594058	2014
KLF5 regulates the integrity and oncogenicity of intestinal stem cells. Cancer research\| PubMed ID: 24626089	2014
Organoid cultures for the analysis of cancer phenotypes. Current opinion in genetics & development\| PubMed ID: 24657539	2014
A promoter-level mammalian expression atlas. Nature\| PubMed ID: 24670764	2014
Selection of personalized patient therapy through the use of knowledge-based computational models that identify tumor-driving signal transduction pathways. Cancer research\| PubMed ID: 24695361	2014
Loss of syntaxin 3 causes variant microvillus inclusion disease. Gastroenterology\| PubMed ID: 24726755	2014
Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer. Nature genetics\| PubMed ID: 24816253	2014
Stem Cells Marked by the R-Spondin Receptor LGR5. Gastroenterology\| PubMed ID: 24859206	2014
Polarizing intestinal epithelial cells electrically through Ror2. Journal of cell science\| PubMed ID: 24928904	2014
Human intestinal tissue with adult stem cell properties derived from pluripotent stem cells. Stem cell reports\| PubMed ID: 24936470	2014
Paneth cells. Current biology : CB\| PubMed ID: 24937274	2014
Leucine-rich repeat-containing G-protein-coupled Receptor 5 marks short-term hematopoietic stem and progenitor cells during mouse embryonic development. The Journal of biological chemistry\| PubMed ID: 24966324	2014
Paneth cell extrusion and release of antimicrobial products is directly controlled by immune cell-derived IFN-γ. The Journal of experimental medicine\| PubMed ID: 24980747	2014
Genome sequencing of normal cells reveals developmental lineages and mutational processes. Nature\| PubMed ID: 25043003	2014
Glial origin of mesenchymal stem cells in a tooth model system. Nature\| PubMed ID: 25079316	2014
Mapping early fate determination in Lgr5+ crypt stem cells using a novel Ki67-RFP allele. The EMBO journal\| PubMed ID: 25092767	2014
Immune deficiency-related enteropathy-lymphocytopenia-alopecia syndrome results from tetratricopeptide repeat domain 7A deficiency. The Journal of allergy and clinical immunology\| PubMed ID: 25174867	2014
Identification of multipotent luminal progenitor cells in human prostate organoid cultures. Cell\| PubMed ID: 25201529	2014
Organoid cultures derived from patients with advanced prostate cancer. Cell\| PubMed ID: 25201530	2014
Inducible in vivo silencing of Brd4 identifies potential toxicities of sustained BET protein inhibition. Cell reports\| PubMed ID: 25242322	2014
Robust cre-mediated recombination in small intestinal stem cells utilizing the olfm4 locus. Stem cell reports\| PubMed ID: 25254337	2014
A20 controls intestinal homeostasis through cell-specific activities. Nature communications\| PubMed ID: 25267258	2014
Stem cell signaling. An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control. Science (New York, N.Y.)\| PubMed ID: 25278615	2014
In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection. Gastroenterology\| PubMed ID: 25307862	2015
Plasticity within stem cell hierarchies in mammalian epithelia. Trends in cell biology\| PubMed ID: 25308311	2015
Large-scale identification of coregulated enhancer networks in the adult human brain. Cell reports\| PubMed ID: 25373911	2014
Targeting development of incretin-producing cells increases insulin secretion. The Journal of clinical investigation\| PubMed ID: 25500886	2015
Transformation of intestinal stem cells into gastric stem cells on loss of transcription factor Cdx2. Nature communications\| PubMed ID: 25500896	2014
Long-term culture of genome-stable bipotent stem cells from adult human liver. Cell\| PubMed ID: 25533785	2015
Organoid models of human and mouse ductal pancreatic cancer. Cell\| PubMed ID: 25557080	2015
Microbiota controls the homeostasis of glial cells in the gut lamina propria. Neuron\| PubMed ID: 25578362	2015
Ascl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts. Cell stem cell\| PubMed ID: 25620640	2015
Generation and analysis of mouse intestinal tumors and organoids harboring APC and K-Ras mutations. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 25636467	2015
Germline deletions in the tumour suppressor gene FOCAD are associated with polyposis and colorectal cancer development. The Journal of pathology\| PubMed ID: 25712196	2015
Premigratory and migratory neural crest cells are multipotent in vivo. Cell stem cell\| PubMed ID: 25748934	2015
An EphB-Abl signaling pathway is associated with intestinal tumor initiation and growth. Science translational medicine\| PubMed ID: 25834110	2015
Frizzled7 functions as a Wnt receptor in intestinal epithelial Lgr5(+) stem cells. Stem cell reports\| PubMed ID: 25892522	2015
Efficient intracellular delivery of native proteins. Cell\| PubMed ID: 25910214	2015
Sequential cancer mutations in cultured human intestinal stem cells. Nature\| PubMed ID: 25924068	2015
Prospective derivation of a living organoid biobank of colorectal cancer patients. Cell\| PubMed ID: 25957691	2015
Q&A: Hans Clevers. Banking on organoids. Nature\| PubMed ID: 25970453	2015
Repairing organs: lessons from intestine and liver. Trends in genetics : TIG\| PubMed ID: 25989898	2015
Porcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43;Znrf3-mutant neoplasia. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26023187	2015
Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer. Cell\| PubMed ID: 26091037	2015
SnapShot: Growing Organoids from Stem Cells. Cell\| PubMed ID: 26091044	2015
Expanding intestinal stem cells in culture. Cell research\| PubMed ID: 26169607	2015
Development and application of human adult stem or progenitor cell organoids. Nature reviews. Nephrology\| PubMed ID: 26215513	2015
In Situ Hybridization to Identify Gut Stem Cells. Current protocols in stem cell biology\| PubMed ID: 26237569	2015
Single-cell messenger RNA sequencing reveals rare intestinal cell types. Nature\| PubMed ID: 26287467	2015
Lgr4 Controls Specialization of Female Gonads in Mice. Biology of reproduction\| PubMed ID: 26333992	2015
An inducible mouse model for microvillus inclusion disease reveals a role for myosin Vb in apical and basolateral trafficking. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26392529	2015
Pre-clinical Models of Pancreatic Ductal Adenocarcinoma. The Journal of pathology\| PubMed ID: 26419819	2015
Disease Modeling and Gene Therapy of Copper Storage Disease in Canine Hepatic Organoids. Stem cell reports\| PubMed ID: 26455412	2015
Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastases. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26460009	2015
Radical Sabbaticals. Cell\| PubMed ID: 26544929	2015
The gut microbiota keeps enteric glial cells on the move; prospective roles of the gut epithelium and immune system. Gut microbes\| PubMed ID: 26558327	2015
Dynamics of Lgr6⁺ Progenitor Cells in the Hair Follicle, Sebaceous Gland, and Interfollicular Epidermis. Stem cell reports\| PubMed ID: 26607954	2015
Identification of Different Classes of Luminal Progenitor Cells within Prostate Tumors. Cell reports\| PubMed ID: 26628377	2015
STEM CELLS. What is an adult stem cell? Science (New York, N.Y.)\| PubMed ID: 26659043	2015
Long-Term In Vitro Expansion of Salivary Gland Stem Cells Driven by Wnt Signals. Stem cell reports\| PubMed ID: 26724906	2016
Reparative inflammation takes charge of tissue regeneration. Nature\| PubMed ID: 26791721	2016
Organoid culture systems for prostate epithelial and cancer tissue. Nature protocols\| PubMed ID: 26797458	2016
Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters. Cell stem cell\| PubMed ID: 26831517	2016
Visualization of a short-range Wnt gradient in the intestinal stem-cell niche. Nature\| PubMed ID: 26863187	2016
Generation and characterization of rat liver stem cell lines and their engraftment in a rat model of liver failure. Scientific reports\| PubMed ID: 26915950	2016
Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation. Nature communications\| PubMed ID: 26955760	2016
Tissue-specific designs of stem cell hierarchies. Nature cell biology\| PubMed ID: 26999737	2016
Modeling pancreatic cancer with organoids. Trends in cancer\| PubMed ID: 27135056	2016
Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation. Cell stem cell\| PubMed ID: 27184401	2016
TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype. EMBO molecular medicine\| PubMed ID: 27221051	2016
CRISPR/Cas9-Mediated Genome Editing of Mouse Small Intestinal Organoids. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 27246017	2016
Organoid biobanking: identifying the ethics: Organoids revive old and raise new ethical challenges for basic research and therapeutic use. EMBO reports\| PubMed ID: 27296278	2016
Model organoids provide new research opportunities for ductal pancreatic cancer. Molecular & cellular oncology\| PubMed ID: 27308531	2016
Modeling Development and Disease with Organoids. Cell\| PubMed ID: 27315476	2016
RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation. Gut\| PubMed ID: 27329244	2016
Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis. Science translational medicine\| PubMed ID: 27334259	2016
De Novo Prediction of Stem Cell Identity using Single-Cell Transcriptome Data. Cell stem cell\| PubMed ID: 27345837	2016
Analysis of neural crest-derived clones reveals novel aspects of facial development. Science advances\| PubMed ID: 27493992	2016
Who Is in the Driver's Seat: Tracing Cancer Genes Using CRISPR-Barcoding. Molecular cell\| PubMed ID: 27494556	2016
Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma. Nature communications\| PubMed ID: 27558455	2016
Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation. Nature protocols\| PubMed ID: 27560176	2016
Reg4+ deep crypt secretory cells function as epithelial niche for Lgr5+ stem cells in colon. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27573849	2016
The Generation of Organoids for Studying Wnt Signaling. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 27590160	2016
Organoids: Modeling Development and the Stem Cell Niche in a Dish. Developmental cell\| PubMed ID: 27676432	2016
Tissue-specific mutation accumulation in human adult stem cells during life. Nature\| PubMed ID: 27698416	2016
Generation of an inducible colon-specific Cre enzyme mouse line for colon cancer research. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27708166	2016
Programs for the persistence, vigilance and control of human CD8(+) lung-resident memory T cells. Nature immunology\| PubMed ID: 27776108	2016
Regulation and plasticity of intestinal stem cells during homeostasis and regeneration. Development (Cambridge, England)\| PubMed ID: 27802133	2016
Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening. eLife\| PubMed ID: 27845624	2016
Designer matrices for intestinal stem cell and organoid culture. Nature\| PubMed ID: 27851739	2016
Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors. Nature medicine\| PubMed ID: 27869803	2017
Induced Quiescence of Lgr5+ Stem Cells in Intestinal Organoids Enables Differentiation of Hormone-Producing Enteroendocrine Cells. Cell stem cell\| PubMed ID: 27939219	2017
Aberrantly expressed LGR4 empowers Wnt signaling in multiple myeloma by hijacking osteoblast-derived R-spondins. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28028233	2017
IκBNS enhances follicular helper T-cell differentiation and function downstream of ASCl2. The Journal of allergy and clinical immunology\| PubMed ID: 28040417	2016
Personalized Proteome Profiles of Healthy and Tumor Human Colon Organoids Reveal Both Individual Diversity and Basic Features of Colorectal Cancer. Cell reports\| PubMed ID: 28052255	2017
Erratum: Programs for the persistence, vigilance and control of human CD8(+) lung-resident memory T cells. Nature immunology\| PubMed ID: 28102212	2017
Human tissues in a dish: The research and ethical implications of organoid technology. Science (New York, N.Y.)\| PubMed ID: 28104841	2017
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