Peter Cherepanov

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 56	2016

Other Publications

Article	Year
Role of Yersinia murine toxin in survival of Yersinia pestis in the midgut of the flea vector. Science (New York, N.Y.)\| PubMed ID: 11976454	2002
New class of HIV integrase inhibitors that block viral replication in cell culture. Current biology : CB\| PubMed ID: 12176326	2002
In search of authentic inhibitors of HIV-1 integration. Antiviral chemistry & chemotherapy\| PubMed ID: 12180645	2002
HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells. The Journal of biological chemistry\| PubMed ID: 12407101	2003
env chimeric virus technology for evaluating human immunodeficiency virus susceptibility to entry inhibitors. Antimicrobial agents and chemotherapy\| PubMed ID: 12435701	2002
pH6 antigen of Yersinia pestis interacts with plasma lipoproteins and cell membranes. Journal of lipid research\| PubMed ID: 12576514	2003
LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells. The Journal of biological chemistry\| PubMed ID: 12796494	2003
Expression of HIV-1 integrase in CEM cells inhibits HIV-1 replication. The journal of gene medicine\| PubMed ID: 15026988	2004
Identification and characterization of a functional nuclear localization signal in the HIV-1 integrase interactor LEDGF/p75. The Journal of biological chemistry\| PubMed ID: 15163664	2004
Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase. The Journal of biological chemistry\| PubMed ID: 15371438	2004
Class II integrase mutants with changes in putative nuclear localization signals are primarily blocked at a postnuclear entry step of human immunodeficiency virus type 1 replication. Journal of virology\| PubMed ID: 15542626	2004
Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75. Nature structural & molecular biology\| PubMed ID: 15895093	2005
Mutations in both env and gag genes are required for HIV-1 resistance to the polysulfonic dendrimer SPL2923, as corroborated by chimeric virus technology. Antiviral chemistry & chemotherapy\| PubMed ID: 16130523	2005
Lys-34, dispensable for integrase catalysis, is required for preintegration complex function and human immunodeficiency virus type 1 replication. Journal of virology\| PubMed ID: 16160186	2005
Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16260736	2005
A tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivo. Nucleic acids research\| PubMed ID: 16549878	2006
Transcriptional co-activator p75 binds and tethers the Myc-interacting protein JPO2 to chromatin. Journal of cell science\| PubMed ID: 16735438	2006
Structure-based mutagenesis of the integrase-LEDGF/p75 interface uncouples a strict correlation between in vitro protein binding and HIV-1 fitness. Virology\| PubMed ID: 16959283	2007
LEDGF/p75 interacts with divergent lentiviral integrases and modulates their enzymatic activity in vitro. Nucleic acids research\| PubMed ID: 17158150	2007
LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration. Genes & development\| PubMed ID: 17639082	2007
The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication. PLoS pathogens\| PubMed ID: 18369482	2008
Functional and structural characterization of the integrase from the prototype foamy virus. Nucleic acids research\| PubMed ID: 19036793	2009
A novel co-crystal structure affords the design of gain-of-function lentiviral integrase mutants in the presence of modified PSIP1/LEDGF/p75. PLoS pathogens\| PubMed ID: 19132083	2009
HIV-1 exploits importin 7 to maximize nuclear import of its DNA genome. Retrovirology\| PubMed ID: 19193229	2009
The SET complex acts as a barrier to autointegration of HIV-1. PLoS pathogens\| PubMed ID: 19266025	2009
Structural basis for functional tetramerization of lentiviral integrase. PLoS pathogens\| PubMed ID: 19609359	2009
Application of general formulas for the correction of a lattice-translocation defect in crystals of a lentiviral integrase in complex with LEDGF. Acta crystallographica. Section D, Biological crystallography\| PubMed ID: 19690374	2009
Transcriptional co-activator LEDGF interacts with Cdc7-activator of S-phase kinase (ASK) and stimulates its enzymatic activity. The Journal of biological chemistry\| PubMed ID: 19864417	2010
Retroviral intasome assembly and inhibition of DNA strand transfer. Nature\| PubMed ID: 20118915	2010
Integrase illuminated. EMBO reports\| PubMed ID: 20428106	2010
Structure-based modeling of the functional HIV-1 intasome and its inhibition. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20733078	2010
Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21030679	2010
The mechanism of retroviral integration from X-ray structures of its key intermediates. Nature\| PubMed ID: 21068843	2010
Structural biology of retroviral DNA integration. Virology\| PubMed ID: 21216426	2011
Structural insights into the retroviral DNA integration apparatus. Current opinion in structural biology\| PubMed ID: 21277766	2011
Structural and functional analyses of the second-generation integrase strand transfer inhibitor dolutegravir (S/GSK1349572). Molecular pharmacology\| PubMed ID: 21719464	2011
The Interaction Between Lentiviral Integrase and LEDGF: Structural and Functional Insights. Viruses\| PubMed ID: 21994569	2009
The structural biology of HIV-1: mechanistic and therapeutic insights. Nature reviews. Microbiology\| PubMed ID: 22421880	2012
3'-processing and strand transfer catalysed by retroviral integrase in crystallo. The EMBO journal\| PubMed ID: 22580823	2012
Solution conformations of prototype foamy virus integrase and its stable synaptic complex with U5 viral DNA. Structure (London, England : 1993)\| PubMed ID: 23000384	2012
HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase... Nucleic acids research\| PubMed ID: 23042676	2012
Crystal structure of human CDC7 kinase in complex with its activator DBF4. Nature structural & molecular biology\| PubMed ID: 23064647	2012
Activities, crystal structures, and molecular dynamics of dihydro-1H-isoindole derivatives, inhibitors of HIV-1 integrase. ACS chemical biology\| PubMed ID: 23075516	2013
Centralspindlin links the mitotic spindle to the plasma membrane during cytokinesis. Nature\| PubMed ID: 23235882	2012
Bromo- and extraterminal domain chromatin regulators serve as cofactors for murine leukemia virus integration. Journal of virology\| PubMed ID: 24049186	2013
Structural basis for nuclear import of splicing factors by human Transportin 3. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24449914	2014
Integrase residues that determine nucleotide preferences at sites of HIV-1 integration: implications for the mechanism of target DNA binding. Nucleic acids research\| PubMed ID: 24520116	2014
Efficient Transduction of LEDGF/p75 Mutant Cells by Gain-of-Function HIV-1 Integrase Mutant Viruses. Molecular therapy. Methods & clinical development\| PubMed ID: 25383358	2014
Retroviral Integrase Structure and DNA Recombination Mechanism. Microbiology spectrum\| PubMed ID: 25705574	2014
Key determinants of target DNA recognition by retroviral intasomes. Retrovirology\| PubMed ID: 25924943	2015
Structural basis for retroviral integration into nucleosomes. Nature\| PubMed ID: 26061770	2015
Retroviral Integrase Structure and DNA Recombination Mechanism. Microbiology spectrum\| PubMed ID: 26104441	2014
HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant Mutant Integrases. ACS chemical biology\| PubMed ID: 26808478	2016
Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function. Nature\| PubMed ID: 26887496	2016