Guy Lippens

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 25	2016

Other Publications

Article	Year
Molecular implication of PP2A and Pin1 in the Alzheimer's disease specific hyperphosphorylation of Tau. PloS one\| PubMed ID: 21731772	2011
Solid-phase enolate chemistry investigated using HR-MAS NMR spectroscopy. The Journal of organic chemistry\| PubMed ID: 11798327	2002
Solution NMR study of the monomeric form of p13suc1 protein sheds light on the hinge region determining the affinity for a phosphorylated substrate. The Journal of biological chemistry\| PubMed ID: 11812792	2002
Osmoregulated periplasmic glucans of the free-living photosynthetic bacterium Rhodobacter sphaeroides. European journal of biochemistry\| PubMed ID: 12027884	2002
Solution structure of the single-domain prolyl cis/trans isomerase PIN1At from Arabidopsis thaliana. Journal of molecular biology\| PubMed ID: 12079389	2002
Assignment of the 1H, 13C and 15N resonances and secondary structure of the monomeric p13suc1 protein of Saccharomyces pombe. Journal of biomolecular NMR\| PubMed ID: 12153042	2002
Resin dynamics contributes to the NMR line broadening of organic molecules grafted onto a polystyrene resin. Journal of magnetic resonance (San Diego, Calif. : 1997)\| PubMed ID: 12165259	2002
Fine-tuned characterization at the solid/solution interface of organotin compounds grafted onto cross-linked polystyrene by using high-resolution MAS NMR spectroscopy. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 12203323	2002
Pin1: a therapeutic target in Alzheimer neurodegeneration. Journal of molecular neuroscience : MN\| PubMed ID: 12540053	2002
HRMAS NMR observation of beta-sheet secondary structure on a water swollen solid support. Journal of peptide science : an official publication of the European Peptide Society\| PubMed ID: 12587882	2003
Restricted linear least square treatment processing of heteronuclear spectra of biomolecules using the ANAFOR strategy. Journal of magnetic resonance (San Diego, Calif. : 1997)\| PubMed ID: 12713967	2003
Cobatoxin 1 from Centruroides noxius scorpion venom: chemical synthesis, three-dimensional structure in solution, pharmacology and docking on K+ channels. The Biochemical journal\| PubMed ID: 14498829	2004
Neurofibrillary degeneration of the Alzheimer-type: an alternate pathway to neuronal apoptosis? Biochemical pharmacology\| PubMed ID: 14555242	2003
Proline-directed random-coil chemical shift values as a tool for the NMR assignment of the tau phosphorylation sites. Chembiochem : a European journal of chemical biology\| PubMed ID: 14695515	2004
The peptidyl prolyl cis/trans-isomerase Pin1 recognizes the phospho-Thr212-Pro213 site on Tau. Biochemistry\| PubMed ID: 14967043	2004
Structural analysis of Escherichia coli OpgG, a protein required for the biosynthesis of osmoregulated periplasmic glucans. Journal of molecular biology\| PubMed ID: 15313617	2004
A small CDC25 dual-specificity tyrosine-phosphatase isoform in Arabidopsis thaliana. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15329414	2004
Characterization of the Arabidopsis thaliana Arath;CDC25 dual-specificity tyrosine phosphatase. Biochemical and biophysical research communications\| PubMed ID: 15336525	2004
Accepting its random coil nature allows a partial NMR assignment of the neuronal Tau protein. Chembiochem : a European journal of chemical biology\| PubMed ID: 15532033	2004
Practical aspects of shimming a high resolution magic angle spinning probe. Journal of magnetic resonance (San Diego, Calif. : 1997)\| PubMed ID: 15705516	2005
Development of a high-resolution magic-angle spinning nuclear magnetic resonance identity assay of the capsular polysaccharide from Haemophilus influenzae type b present in cetavlon precipit... Analytical biochemistry\| PubMed ID: 15707931	2005
Monitoring of the ethionamide pro-drug activation in mycobacteria by (1)H high resolution magic angle spinning NMR. Biochemical and biophysical research communications\| PubMed ID: 15850780	2005
Regulation of Pin1 peptidyl-prolyl cis/trans isomerase activity by its WW binding module on a multi-phosphorylated peptide of Tau protein. FEBS letters\| PubMed ID: 16024016	2005
High-resolution magic angle spinning NMR of the neuronal tau protein integrated in Alzheimer's-like paired helical fragments. Journal of the American Chemical Society\| PubMed ID: 16028903	2005
Control of protein-protein interactions: structure-based discovery of low molecular weight inhibitors of the interactions between Pin1 WW domain and phosphopeptides. Journal of medicinal chemistry\| PubMed ID: 16033261	2005
Regions of tau implicated in the paired helical fragment core as defined by NMR. Chembiochem : a European journal of chemical biology\| PubMed ID: 16196016	2005
Studying the natively unfolded neuronal Tau protein by solution NMR spectroscopy. Protein and peptide letters\| PubMed ID: 16515451	2006
NMR analysis of a Tau phosphorylation pattern. Journal of the American Chemical Society\| PubMed ID: 16536530	2006
Pin1 allows for differential Tau dephosphorylation in neuronal cells. Molecular and cellular neurosciences\| PubMed ID: 16697218	2006
Arabidopsis PASTICCINO2 is an antiphosphatase involved in regulation of cyclin-dependent kinase A. The Plant cell\| PubMed ID: 16698944	2006
ELISE NMR: experimental liquid sealing of NMR samples. Journal of magnetic resonance (San Diego, Calif. : 1997)\| PubMed ID: 16709462	2006
New DEFT sequences for the acquisition of one-dimensional carbon NMR spectra of small unlabelled molecules. Magnetic resonance in chemistry : MRC\| PubMed ID: 16883554	2006
Selective intracellular accumulation of the major metabolite issued from the activation of the prodrug ethionamide in mycobacteria. The Journal of antimicrobial chemotherapy\| PubMed ID: 16895935	2006
Structural impact of heparin binding to full-length Tau as studied by NMR spectroscopy. Biochemistry\| PubMed ID: 17029411	2006
NMR investigation of the interaction between the neuronal protein tau and the microtubules. Biochemistry\| PubMed ID: 17311412	2007
Structural and functional characterization of the interaction between cyclophilin B and a heparin-derived oligosaccharide. The Journal of biological chemistry\| PubMed ID: 17855358	2007
Contribution of rotational diffusion to pulsed field gradient diffusion measurements. The Journal of chemical physics\| PubMed ID: 17887855	2007
Microinjection of recombinant O-GlcNAc transferase potentiates Xenopus oocytes M-phase entry. Biochemical and biophysical research communications\| PubMed ID: 18298951	2008
Measurement of amyloid fibril length distributions by inclusion of rotational motion in solution NMR diffusion measurements. Angewandte Chemie (International ed. in English)\| PubMed ID: 18350531	2008
NMR observation of Tau in Xenopus oocytes. Journal of magnetic resonance (San Diego, Calif. : 1997)\| PubMed ID: 18378475	2008
Sandwich-ELISE NMR: reducing the sample volume of NMR samples. Journal of magnetic resonance (San Diego, Calif. : 1997)\| PubMed ID: 18455452	2008
The talin rod IBS2 alpha-helix interacts with the beta3 integrin cytoplasmic tail membrane-proximal helix by establishing charge complementary salt bridges. The Journal of biological chemistry\| PubMed ID: 18577523	2008
Graphical interpretation of Boolean operators for protein NMR assignments. Journal of biomolecular NMR\| PubMed ID: 18762868	2008
Alzheimer disease specific phosphoepitopes of Tau interfere with assembly of tubulin but not binding to microtubules. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 19074508	2009
Tau aggregation in Alzheimer's disease: what role for phosphorylation? Prion\| PubMed ID: 19164903	2007
Domain 3 of non-structural protein 5A from hepatitis C virus is natively unfolded. Biochemical and biophysical research communications\| PubMed ID: 19249289	2009
Selective backbone labelling of ILV methyl labelled proteins. Journal of biomolecular NMR\| PubMed ID: 19288066	2009
Hepatitis C virus NS5A protein is a substrate for the peptidyl-prolyl cis/trans isomerase activity of cyclophilins A and B. The Journal of biological chemistry\| PubMed ID: 19297321	2009
Fluorescent BODIPY-based Zn(II) complex as a molecular probe for selective detection of neurofibrillary tangles in the brains of Alzheimer's disease patients. Journal of the American Chemical Society\| PubMed ID: 19368380	2009
Structural basis for the non-immunosuppressive character of the cyclosporin A analogue Debio 025. Biochemistry\| PubMed ID: 20423153	2010
The domain 2 of the HCV NS5A protein is intrinsically unstructured. Protein and peptide letters\| PubMed ID: 20450484	2010
Microtubule and MAPs: thermodynamics of complex formation by AUC, ITC, fluorescence, and NMR. Methods in cell biology\| PubMed ID: 20466148	2010
NMR spectroscopy of the neuronal tau protein: normal function and implication in Alzheimer's disease. Biochemical Society transactions\| PubMed ID: 20658994	2010
Spectroscopic studies of GSK3{beta} phosphorylation of the neuronal tau protein and its interaction with the N-terminal domain of apolipoprotein E. The Journal of biological chemistry\| PubMed ID: 20679343	2010
DEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5A. PloS one\| PubMed ID: 21060866	2010
Intermolecular interaction studies using small volumes. Magnetic resonance in chemistry : MRC\| PubMed ID: 21162136	2011
Identification of O-GlcNAc sites within peptides of the Tau protein and their impact on phosphorylation. Molecular bioSystems\| PubMed ID: 21327254	2011
Oleuropein and derivatives from olives as Tau aggregation inhibitors. Neurochemistry international\| PubMed ID: 21333710	2011
Mice lacking phosphatase PP2A subunit PR61/B'delta (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3beta. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21482799	2011
Comparative analysis of Erk phosphorylation suggests a mixed strategy for measuring phospho-form distributions. Molecular systems biology\| PubMed ID: 21487401	2011
Domain 3 of NS5A protein from the hepatitis C virus has intrinsic alpha-helical propensity and is a substrate of cyclophilin A. The Journal of biological chemistry\| PubMed ID: 21489988	2011
Substrate recognition by the POTRA domains of TpsB transporter FhaC. Molecular microbiology\| PubMed ID: 21542859	2011
Molecular basis for an ancient partnership between prolyl isomerase Pin1 and phosphatase inhibitor-2. Biochemistry\| PubMed ID: 21714498	2011
Systematic identification of tubulin-interacting fragments of the microtubule-associated protein Tau leads to a highly efficient promoter of microtubule assembly. The Journal of biological chemistry\| PubMed ID: 21757739	2011
Glycerol and glycerol carbonate as ultraviscous solvents for mixture analysis by NMR. Journal of magnetic resonance (San Diego, Calif. : 1997)\| PubMed ID: 21802324	2011
Characterization of the AT180 epitope of phosphorylated Tau protein by a combined nuclear magnetic resonance and fluorescence spectroscopy approach. Biochemical and biophysical research communications\| PubMed ID: 21871442	2011
Structural characterization by nuclear magnetic resonance of the impact of phosphorylation in the proline-rich region of the disordered Tau protein. Proteins\| PubMed ID: 22072628	2012
Structural activation of the transcriptional repressor EthR from Mycobacterium tuberculosis by single amino acid change mimicking natural and synthetic ligands. Nucleic acids research\| PubMed ID: 22156370	2012
Differential contribution of the repeats to heparin binding of HBHA, a major adhesin of Mycobacterium tuberculosis. PloS one\| PubMed ID: 22403657	2012
Towards understanding the phosphorylation code of tau. Biochemical Society transactions\| PubMed ID: 22817719	2012
Post-translational modification: nature's escape from genetic imprisonment and the basis for dynamic information encoding. Wiley interdisciplinary reviews. Systems biology and medicine\| PubMed ID: 22899623	2012
Tau pathology modulates Pin1 post-translational modifications and may be relevant as biomarker. Neurobiology of aging\| PubMed ID: 22926167	2013
Cell signaling, post-translational protein modifications and NMR spectroscopy. Journal of biomolecular NMR\| PubMed ID: 23011410	2012
Hepatitis C virus NS5B and host cyclophilin A share a common binding site on NS5A. The Journal of biological chemistry\| PubMed ID: 23152499	2012
Unraveling a phosphorylation event in a folded protein by NMR spectroscopy: phosphorylation of the Pin1 WW domain by PKA. Journal of biomolecular NMR\| PubMed ID: 23456038	2013
A new strategy for sequential assignment of intrinsically unstructured proteins based on 15N single isotope labelling. Journal of magnetic resonance (San Diego, Calif. : 1997)\| PubMed ID: 24018100	2013
Dissociation kinetics of a binary complex in solution by protein displacement. Angewandte Chemie (International ed. in English)\| PubMed ID: 24123878	2013
Increasing brain protein O-GlcNAc-ylation mitigates breathing defects and mortality of Tau.P301L mice. PloS one\| PubMed ID: 24376810	2013
A functional fragment of Tau forms fibers without the need for an intermolecular cysteine bridge. Biochemical and biophysical research communications\| PubMed ID: 24502945	2014
Immunophilin FKBP52 induces Tau-P301L filamentous assembly in vitro and modulates its activity in a model of tauopathy. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24623856	2014
Nuclear magnetic resonance analysis of the acetylation pattern of the neuronal Tau protein. Biochemistry\| PubMed ID: 24708343	2014
Ranking high affinity ligands of low solubility by NMR spectroscopy. ACS medicinal chemistry letters\| PubMed ID: 24900335	2011
Mechanism of Tau-promoted microtubule assembly as probed by NMR spectroscopy. Journal of the American Chemical Society\| PubMed ID: 25162583	2014
Phosphorylation in intrinsically disordered regions regulates the activity of Neurogenin2. BMC biochemistry\| PubMed ID: 25374254	2014
H/D exchange of a (15)N labelled Tau fragment as measured by a simple Relax-EXSY experiment. Journal of magnetic resonance (San Diego, Calif. : 1997)\| PubMed ID: 25462944	2014
Tau monoclonal antibody generation based on humanized yeast models: impact on Tau oligomerization and diagnostics. The Journal of biological chemistry\| PubMed ID: 25540200	2015
Nuclear magnetic resonance spectroscopy characterization of interaction of Tau with DNA and its regulation by phosphorylation. Biochemistry\| PubMed ID: 25623359	2015
A Phosphorylation-Induced Turn Defines the Alzheimer's Disease AT8 Antibody Epitope on the Tau Protein. Angewandte Chemie (International ed. in English)\| PubMed ID: 25881502	2015
The FK506-binding protein FKBP52 in vitro induces aggregation of truncated Tau forms with prion-like behavior. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 25888602	2015
A Proline-Tryptophan Turn in the Intrinsically Disordered Domain 2 of NS5A Protein Is Essential for Hepatitis C Virus RNA Replication. The Journal of biological chemistry\| PubMed ID: 26085105	2015
Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice. Nature communications\| PubMed ID: 26394692	2015
Tau phosphorylation regulates the interaction between BIN1's SH3 domain and Tau's proline-rich domain. Acta neuropathologica communications\| PubMed ID: 26395440	2015
Characterization of Neuronal Tau Protein as a Target of Extracellular Signal-regulated Kinase. The Journal of biological chemistry\| PubMed ID: 26858248	2016
Studying Intrinsically Disordered Proteins under True In Vivo Conditions by Combined Cross-Polarization and Carbonyl-Detection NMR Spectroscopy. Angewandte Chemie (International ed. in English)\| PubMed ID: 27159340	2016
NMR Meets Tau: Insights into Its Function and Pathology. Biomolecules\| PubMed ID: 27338491	2016
A β-Turn Motif in the Steroid Hormone Receptor's Ligand-Binding Domains Interacts with the Peptidyl-prolyl Isomerase (PPIase) Catalytic Site of the Immunophilin FKBP52. Biochemistry\| PubMed ID: 27641460	2016
Molecular Dynamics Simulation of Tau Peptides for the Investigation of Conformational Changes Induced by Specific Phosphorylation Patterns. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 27975243	2017
The Study of Posttranslational Modifications of Tau Protein by Nuclear Magnetic Resonance Spectroscopy: Phosphorylation of Tau Protein by ERK2 Recombinant Kinase and Rat Brain Extract, and A... Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 27975251	2017