Peter Hegemann

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 26	2017

Other Publications

Article	Year
Evidence for a light-induced H(+) conductance in the eye of the green alga Chlamydomonas reinhardtii. Biophysical journal\| PubMed ID: 11806916	2002
Channelrhodopsin-1: a light-gated proton channel in green algae. Science (New York, N.Y.)\| PubMed ID: 12089443	2002
Phot-LOV1: photocycle of a blue-light receptor domain from the green alga Chlamydomonas reinhardtii. Biophysical journal\| PubMed ID: 12547798	2003
Crystal structures and molecular mechanism of a light-induced signaling switch: The Phot-LOV1 domain from Chlamydomonas reinhardtii. Biophysical journal\| PubMed ID: 12668455	2003
Characterization of a flavin radical product in a C57M mutant of a LOV1 domain by electron paramagnetic resonance. Biochemistry\| PubMed ID: 12859197	2003
Irreversible photoreduction of flavin in a mutated Phot-LOV1 domain. Biochemistry\| PubMed ID: 12924934	2003
Channelrhodopsin-2, a directly light-gated cation-selective membrane channel. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14615590	2003
Recording of blue light-induced energy and volume changes within the wild-type and mutated phot-LOV1 domain from Chlamydomonas reinhardtii. Biophysical journal\| PubMed ID: 14747340	2004
"Vision" in single-celled algae. News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society\| PubMed ID: 15143209	2004
On the reaction mechanism of adduct formation in LOV domains of the plant blue-light receptor phototropin. Journal of the American Chemical Society\| PubMed ID: 15339193	2004
Monitoring dynamic expression of nuclear genes in Chlamydomonas reinhardtii by using a synthetic luciferase reporter gene. Plant molecular biology\| PubMed ID: 15604722	2004
Removal of mismatched bases from synthetic genes by enzymatic mismatch cleavage. Nucleic acids research\| PubMed ID: 15800209	2005
The phot LOV2 domain and its interaction with LOV1. Biophysical journal\| PubMed ID: 15879473	2005
Nuclear-gene targeting by using single-stranded DNA avoids illegitimate DNA integration in Chlamydomonas reinhardtii. Eukaryotic cell\| PubMed ID: 16002652	2005
Multiple photocycles of channelrhodopsin. Biophysical journal\| PubMed ID: 16169986	2005
Fast noninvasive activation and inhibition of neural and network activity by vertebrate rhodopsin and green algae channelrhodopsin. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16306259	2005
The photochemistry of the light-, oxygen-, and voltage-sensitive domains in the algal blue light receptor phot. Biopolymers\| PubMed ID: 16552739	2006
H+ -pumping rhodopsin from the marine alga Acetabularia. Biophysical journal\| PubMed ID: 16731558	2006
Hydrogen-bond switching through a radical pair mechanism in a flavin-binding photoreceptor. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16829579	2006
Fast manipulation of cellular cAMP level by light in vivo. Nature methods\| PubMed ID: 17128267	2007
Redox properties of LOV domains: chemical versus photochemical reduction, and influence on the photocycle. Chembiochem : a European journal of chemical biology\| PubMed ID: 17990262	2007
Photoactivation of channelrhodopsin. The Journal of biological chemistry\| PubMed ID: 17993465	2008
Red-shifted optogenetic excitation: a tool for fast neural control derived from Volvox carteri. Nature neuroscience\| PubMed ID: 18432196	2008
Algal sensory photoreceptors. Annual review of plant biology\| PubMed ID: 18444900	2008
Channelrhodopsin-1 initiates phototaxis and photophobic responses in chlamydomonas by immediate light-induced depolarization. The Plant cell\| PubMed ID: 18552201	2008
Dynamics of voltage profile in enzymatic ion transporters, demonstrated in electrokinetics of proton pumping rhodopsin. Biophysical journal\| PubMed ID: 18621842	2008
Hydrogen bond switching among flavin and amino acid side chains in the BLUF photoreceptor observed by ultrafast infrared spectroscopy. Biophysical journal\| PubMed ID: 18708458	2008
Monitoring light-induced structural changes of Channelrhodopsin-2 by UV-visible and Fourier transform infrared spectroscopy. The Journal of biological chemistry\| PubMed ID: 18927082	2008
In vivo generation of flavoproteins with modified cofactors. Journal of molecular biology\| PubMed ID: 19027027	2009
Bi-stable neural state switches. Nature neuroscience\| PubMed ID: 19079251	2009
Nuclear gene targeting in Chlamydomonas as exemplified by disruption of the PHOT gene. Gene\| PubMed ID: 19121376	2009
Glu 87 of channelrhodopsin-1 causes pH-dependent color tuning and fast photocurrent inactivation. Photochemistry and photobiology\| PubMed ID: 19192197	2009
Channelrhodopsins of Volvox carteri are photochromic proteins that are specifically expressed in somatic cells under control of light, temperature, and the sex inducer. Plant physiology\| PubMed ID: 19641026	2009
Mechanistic insights in light-induced cAMP production by photoactivated adenylyl cyclase alpha (PACalpha). Biological chemistry\| PubMed ID: 19747080	2009
The role of key amino acids in the photoactivation pathway of the Synechocystis Slr1694 BLUF domain. Biochemistry\| PubMed ID: 19863128	2009
Blue light induces global and localized conformational changes in the kinase domain of full-length phototropin. Biochemistry\| PubMed ID: 20052995	2010
Ultrafast optogenetic control. Nature neuroscience\| PubMed ID: 20081849	2010
Two open states with progressive proton selectivities in the branched channelrhodopsin-2 photocycle. Biophysical journal\| PubMed ID: 20197028	2010
The branched photocycle of the slow-cycling channelrhodopsin-2 mutant C128T. Journal of molecular biology\| PubMed ID: 20346954	2010
Evolution of the channelrhodopsin photocycle model. Chemphyschem : a European journal of chemical physics and physical chemistry\| PubMed ID: 20349494	2010
Hindered rotation of a cofactor methyl group as a probe for protein-cofactor interaction. Journal of the American Chemical Society\| PubMed ID: 20536240	2010
Fast, repetitive light-activation of CaV3.2 using channelrhodopsin 2. Channels (Austin, Tex.)\| PubMed ID: 20714225	2010
Light modulation of cellular cAMP by a small bacterial photoactivated adenylyl cyclase, bPAC, of the soil bacterium Beggiatoa. The Journal of biological chemistry\| PubMed ID: 21030594	2011
Channelrhodopsin engineering and exploration of new optogenetic tools. Nature methods\| PubMed ID: 21191371	2011
Light-generated paramagnetic intermediates in BLUF domains. Photochemistry and photobiology\| PubMed ID: 21198648	2011
Microbial opsins: a family of single-component tools for optical control of neural activity. Cold Spring Harbor protocols\| PubMed ID: 21363959	2011
High-efficiency channelrhodopsins for fast neuronal stimulation at low light levels. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21504945	2011
Introduction to the Symposium-in Print: Blue light effects. Photochemistry and photobiology\| PubMed ID: 21517885	2011
The hydrogen-bond switch reaction of the Blrb Bluf domain of Rhodobacter sphaeroides. The journal of physical chemistry. B\| PubMed ID: 21627064	2011
Neocortical excitation/inhibition balance in information processing and social dysfunction. Nature\| PubMed ID: 21796121	2011
Rectification of the channelrhodopsin early conductance. Biophysical journal\| PubMed ID: 21889442	2011
Color tuning in binding pocket models of the chlamydomonas-type channelrhodopsins. The journal of physical chemistry. B\| PubMed ID: 22077286	2011
The chromophore structure of the long-lived intermediate of the C128T channelrhodopsin-2 variant. FEBS letters\| PubMed ID: 22094167	2011
The microbial opsin family of optogenetic tools. Cell\| PubMed ID: 22196724	2011
In channelrhodopsin-2 Glu-90 is crucial for ion selectivity and is deprotonated during the photocycle. The Journal of biological chemistry\| PubMed ID: 22219197	2012
Structural model of channelrhodopsin. The Journal of biological chemistry\| PubMed ID: 22241469	2012
Crystal structure of the channelrhodopsin light-gated cation channel. Nature\| PubMed ID: 22266941	2012
Color-tuned channelrhodopsins for multiwavelength optogenetics. The Journal of biological chemistry\| PubMed ID: 22843694	2012
A photochromic histidine kinase rhodopsin (HKR1) that is bimodally switched by ultraviolet and blue light. The Journal of biological chemistry\| PubMed ID: 23027869	2012
Bimodal activation of different neuron classes with the spectrally red-shifted channelrhodopsin chimera C1V1 in Caenorhabditis elegans. PloS one\| PubMed ID: 23056472	2012
Nuclear gene targeting in Chlamydomonas using engineered zinc-finger nucleases. The Plant journal : for cell and molecular biology\| PubMed ID: 23137232	2013
Phototropin influence on eyespot development and regulation of phototactic behavior in Chlamydomonas reinhardtii. The Plant cell\| PubMed ID: 23204408	2012
From channelrhodopsins to optogenetics. EMBO molecular medicine\| PubMed ID: 23339069	2013
Genome of Acanthamoeba castellanii highlights extensive lateral gene transfer and early evolution of tyrosine kinase signaling. Genome biology\| PubMed ID: 23375108	2013
Towards an understanding of channelrhodopsin function: simulations lead to novel insights of the channel mechanism. Journal of molecular biology\| PubMed ID: 23376098	2013
Light-dark adaptation of channelrhodopsin C128T mutant. The Journal of biological chemistry\| PubMed ID: 23439646	2013
Genetically encoded calcium indicators for multi-color neural activity imaging and combination with optogenetics. Frontiers in molecular neuroscience\| PubMed ID: 23459413	2013
Adventure beyond borders of scientific fields with optogenetics. Neuroscience research\| PubMed ID: 23465316	2013
Optogenetic modulation of an adenylate cyclase in Toxoplasma gondii demonstrates a requirement of the parasite cAMP for host-cell invasion and stage differentiation. The Journal of biological chemistry\| PubMed ID: 23525100	2013
Ion selectivity and competition in channelrhodopsins. Biophysical journal\| PubMed ID: 23823227	2013
Biotechnology: Programming genomes with light. Nature\| PubMed ID: 23969454	2013
Of ion pumps, sensors and channels - perspectives on microbial rhodopsins between science and history. Biochimica et biophysica acta\| PubMed ID: 23994288	2014
Gloeobacter rhodopsin, limitation of proton pumping at high electrochemical load. Biophysical journal\| PubMed ID: 24209850	2013
A set of engineered Escherichia coli expression strains for selective isotope and reactivity labeling of amino acid side chains and flavin cofactors. PloS one\| PubMed ID: 24223875	2013
Microbial and animal rhodopsins: structures, functions, and molecular mechanisms. Chemical reviews\| PubMed ID: 24364740	2014
Bistable retinal schiff base photodynamics of histidine kinase rhodopsin HKR1 from Chlamydomonas reinhardtii. Photochemistry and photobiology\| PubMed ID: 24460585	2014
Conversion of channelrhodopsin into a light-gated chloride channel. Science (New York, N.Y.)\| PubMed ID: 24674867	2014
Engineering of a red-light-activated human cAMP/cGMP-specific phosphodiesterase. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24889611	2014
Key residues for the light regulation of the blue light-activated adenylyl cyclase from Beggiatoa sp. Biochemistry\| PubMed ID: 25046330	2014
Absorption and emission spectroscopic characterization of photo-dynamics of photoactivated adenylyl cyclase mutant bPAC-Y7F of Beggiatoa sp. Journal of photochemistry and photobiology. B, Biology\| PubMed ID: 25154810	2014
Upgrading a microplate reader for photobiology and all-optical experiments. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology\| PubMed ID: 25373866	2015
Early formation of the ion-conducting pore in channelrhodopsin-2. Angewandte Chemie (International ed. in English)\| PubMed ID: 25537168	2015
Controlling fertilization and cAMP signaling in sperm by optogenetics. eLife\| PubMed ID: 25601414	2015
Photochemical chromophore isomerization in histidine kinase rhodopsin HKR1. FEBS letters\| PubMed ID: 25836735	2015
Biophysics of Channelrhodopsin. Annual review of biophysics\| PubMed ID: 26098512	2015
Time-resolved infrared spectroscopic techniques as applied to channelrhodopsin. Frontiers in molecular biosciences\| PubMed ID: 26217670	2015
Light-Dark Adaptation of Channelrhodopsin Involves Photoconversion between the all-trans and 13-cis Retinal Isomers. Biochemistry\| PubMed ID: 26237332	2015
The rhodopsin-guanylyl cyclase of the aquatic fungus Blastocladiella emersonii enables fast optical control of cGMP signaling. Science signaling\| PubMed ID: 26268609	2015
Photoactivated cyclases: In memoriam Masakatsu Watanabe. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology\| PubMed ID: 26270352	2015
Optogenetics: 10 years after ChR2 in neurons--views from the community. Nature neuroscience\| PubMed ID: 26308981	2015
An improved chloride-conducting channelrhodopsin for light-induced inhibition of neuronal activity in vivo. Scientific reports\| PubMed ID: 26443033	2015
Optogenetic acidification of synaptic vesicles and lysosomes. Nature neuroscience\| PubMed ID: 26551543	2015
Light-Induced Rearrangement of the β5 Strand in the BLUF Photoreceptor SyPixD (Slr1694). The journal of physical chemistry letters\| PubMed ID: 26631358	2015
Structural foundations of optogenetics: Determinants of channelrhodopsin ion selectivity. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26699459	2016
Identification of a Natural Green Light Absorbing Chloride Conducting Channelrhodopsin from Proteomonas sulcata. The Journal of biological chemistry\| PubMed ID: 26740624	2016
Optogenetic approaches addressing extracellular modulation of neural excitability. Scientific reports\| PubMed ID: 27045897	2016
Unfolding of the C-Terminal Jα Helix in the LOV2 Photoreceptor Domain Observed by Time-Resolved Vibrational Spectroscopy. The journal of physical chemistry letters\| PubMed ID: 27537211	2016
A blue-light photoreceptor mediates the feedback regulation of photosynthesis. Nature\| PubMed ID: 27626383	2016
Photoadduct Formation from the FMN Singlet Excited State in the LOV2 Domain of Chlamydomonas reinhardtii Phototropin. The journal of physical chemistry letters\| PubMed ID: 27766868	2016
Active cortical dendrites modulate perception. Science (New York, N.Y.)\| PubMed ID: 28008068	2016
An Efficient Visual Screen for CRISPR/Cas9 Activity in Arabidopsis thaliana. Frontiers in plant science\| PubMed ID: 28174584	2017
Complex Photochemistry within the Green-Absorbing Channelrhodopsin ReaChR. Biophysical journal\| PubMed ID: 28355544	2017