Thomas Fleming

Affiliated with

Research Area

Biography

Thomas Fleming has not added Biography.
If you are Thomas Fleming and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 11	2017
Publication title Cited by 5	2018

Other Publications

Article	Year
Reactive metabolites as a cause of late diabetic complications. Biochemical Society transactions\| PubMed ID: 24646257	2014
High tissue glucose alters intersomitic blood vessels in zebrafish via methylglyoxal targeting the VEGF receptor signaling cascade. Diabetes\| PubMed ID: 25092676	2015
Methylglyoxal as a new biomarker in patients with septic shock: an observational clinical study. Critical care (London, England)\| PubMed ID: 25498125	2014
Impaired aldehyde dehydrogenase 1 subfamily member 2A-dependent retinoic acid signaling is related with a mesenchymal-like phenotype and an unfavorable prognosis of head and neck squamous ce... Molecular cancer\| PubMed ID: 26634247	2015
Role of the RAGE Axis during the Immune Response after Severe Trauma: A Prospective Pilot Study. Mediators of inflammation\| PubMed ID: 26880860	2015
Receptor for advanced glycation end products (RAGE) knockout reduces fetal dysmorphogenesis in murine diabetic pregnancy. Reproductive toxicology (Elmsford, N.Y.)\| PubMed ID: 27109771	2016
RAGE-mediated inflammation in patients with septic shock. The Journal of surgical research\| PubMed ID: 27229106	2016
Impaired glyoxalase activity is associated with reduced expression of neurotrophic factors and pro-inflammatory processes in diabetic skin cells. Experimental dermatology\| PubMed ID: 27306297	2017
Soluble TREM-1 as a diagnostic and prognostic biomarker in patients with septic shock: an observational clinical study. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals\| PubMed ID: 27319606	2017
Characterization of aggregate load and pattern in living yeast cells by flow cytometry. BioTechniques\| PubMed ID: 27625208	2016
Reduction in ins-7 gene expression in non-neuronal cells of high glucose exposed Caenorhabditis elegans protects from reactive metabolites, preserves neuronal structure and head motility, an... Journal of diabetes and its complications\| PubMed ID: 27776915	2017
Control of diabetic hyperglycaemia and insulin resistance through TSC22D4. Nature communications\| PubMed ID: 27827363	2016
Evidence Against a Role for the Parkinsonism-associated Protein DJ-1 in Methylglyoxal Detoxification. The Journal of biological chemistry\| PubMed ID: 27903648	2017
The Glyoxalase System and Methylglyoxal-Derived Carbonyl Stress in Sepsis: Glycotoxic Aspects of Sepsis Pathophysiology. International journal of molecular sciences\| PubMed ID: 28304355	2017
STZ causes depletion of immune cells in sciatic nerve and dorsal root ganglion in experimental diabetes. Journal of neuroimmunology\| PubMed ID: 28385191	2017
Dicarbonyls and Advanced Glycation End-Products in the Development of Diabetic Complications and Targets for Intervention. International journal of molecular sciences\| PubMed ID: 28475116	2017
Electrical Muscle Stimulation Induces an Increase of VEGFR2 on Circulating Hematopoietic Stem Cells in Patients With Diabetes. Clinical therapeutics\| PubMed ID: 28554530	2017
Dietary sugars, not lipids, drive hypothalamic inflammation. Molecular metabolism\| PubMed ID: 28752053	2017
Reply to Richarme: Evidence against a role of DJ-1 in methylglyoxal detoxification. The Journal of biological chemistry\| PubMed ID: 28778882	2017
A Hepatic GAbp-AMPK Axis Links Inflammatory Signaling to Systemic Vascular Damage. Cell reports\| PubMed ID: 28793265	2017
Hormesis enables cells to handle accumulating toxic metabolites during increased energy flux. Redox biology\| PubMed ID: 28826004	2017
Homeostatic nuclear RAGE-ATM interaction is essential for efficient DNA repair. Nucleic acids research\| PubMed ID: 28977635	2017
The NADPH organizers NoxO1 and p47phox are both mediators of diabetes-induced vascular dysfunction in mice. Redox biology\| PubMed ID: 29195137	2018
Modulation of glutathione peroxidase activity by age-dependent carbonylation in glomeruli of diabetic mice. Journal of diabetes and its complications\| PubMed ID: 29223856	2017
TRPC proteins contribute to development of diabetic retinopathy and regulate glyoxalase 1 activity and methylglyoxal accumulation. Molecular metabolism\| PubMed ID: 29373286	2018
High-glucose toxicity is mediated by AICAR-transformylase/IMP cyclohydrolase and mitigated by AMP-activated protein kinase in . The Journal of biological chemistry\| PubMed ID: 29414769	2018
Effects of the Reactive Metabolite Methylglyoxal on Cellular Signalling, Insulin Action and Metabolism - What We Know in Mammals and What We Can Learn From Yeast. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association\| PubMed ID: 29421830	2018
Risk Factors for Incident Diabetic Polyneuropathy in a Cohort With Screen-Detected Type 2 Diabetes Followed for 13 Years: ADDITION-Denmark. Diabetes care\| PubMed ID: 29487078	2018
Impact of carbonylation on glutathione peroxidase-1 activity in human hyperglycemic endothelial cells. Redox biology\| PubMed ID: 29499564	2018
Cell cycle arrest and cell death correlate with the extent of ischaemia and reperfusion injury in patients following kidney transplantation - results of an observational pilot study. Transplant international : official journal of the European Society for Organ Transplantation\| PubMed ID: 29505681	2018
Elevated Levels of the Reactive Metabolite Methylglyoxal Recapitulate Progression of Type 2 Diabetes. Cell metabolism\| PubMed ID: 29551588	2018
Carnosine Catalyzes the Formation of the Oligo/Polymeric Products of Methylglyoxal. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology\| PubMed ID: 29621776	2018
Impairment of the Akt pathway in transplanted Type 1 diabetic hearts is associated with post-transplant graft injury. Interactive cardiovascular and thoracic surgery\| PubMed ID: 29912386	2018
Dietary stearic acid regulates mitochondria in vivo in humans. Nature communications\| PubMed ID: 30087348	2018