Michael Simons

Affiliated with

Research Area

Biography

Michael Simons has not added Biography.
If you are Michael Simons and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 7	2022
Publication title Cited by 1	2022

Other Publications

Article	Year
The FGF system has a key role in regulating vascular integrity. The Journal of clinical investigation\| PubMed ID: 18776942	2008
Endothelium as master regulator of organ development and growth. Vascular pharmacology\| PubMed ID: 18804188	2009
Syndecan-4 regulates subcellular localization of mTOR Complex2 and Akt activation in a PKCalpha-dependent manner in endothelial cells. Molecular cell\| PubMed ID: 18851840	2008
Syndecan-4 mediates macrophage uptake of group V secretory phospholipase A2-modified LDL. Journal of lipid research\| PubMed ID: 19056705	2009
The antiangiogenic activity of rPAI-1(23) inhibits vasa vasorum and growth of atherosclerotic plaque. Circulation research\| PubMed ID: 19122176	2009
Synectin-dependent regulation of arterial maturation. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 19235722	2009
VEGF and restenosis: the rest of the story. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 19299328	2009
Regulation of vascular integrity. Journal of molecular medicine (Berlin, Germany)\| PubMed ID: 19337719	2009
FRS2 via fibroblast growth factor receptor 1 is required for platelet-derived growth factor receptor beta-mediated regulation of vascular smooth muscle marker gene expression. The Journal of biological chemistry\| PubMed ID: 19339244	2009
Endothelium-driven myocardial growth or nitric oxide at the crossroads. Trends in cardiovascular medicine\| PubMed ID: 19345317	2008
Diabetic monocyte and vascular endothelial growth factor signaling impairment. Circulation\| PubMed ID: 19564554	2009
Suppression of RhoG activity is mediated by a syndecan 4-synectin-RhoGDI1 complex and is reversed by PKCalpha in a Rac1 activation pathway. The Journal of cell biology\| PubMed ID: 19581409	2009
ERK1/2-Akt1 crosstalk regulates arteriogenesis in mice and zebrafish. The Journal of clinical investigation\| PubMed ID: 20237411	2010
Micro computed tomography for vascular exploration. Journal of angiogenesis research\| PubMed ID: 20298533	2010
VEGF receptor 2 endocytic trafficking regulates arterial morphogenesis. Developmental cell\| PubMed ID: 20434959	2010
Role of synectin in lymphatic development in zebrafish and frogs. Blood\| PubMed ID: 20631376	2010
Cell communications in the heart. Circulation\| PubMed ID: 20805439	2010
Auxiliary and autonomous proteoglycan signaling networks. Methods in enzymology\| PubMed ID: 20816202	2010
Phosphorylation of VE-cadherin controls endothelial phenotypes via p120-catenin coupling and Rac1 activation. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 21037229	2011
Antiangiogenic activity of rPAI-1(23) promotes vasa vasorum regression in hypercholesterolemic mice through a plasmin-dependent mechanism. Circulation research\| PubMed ID: 21546607	2011
FGF-dependent regulation of VEGF receptor 2 expression in mice. The Journal of clinical investigation\| PubMed ID: 21633168	2011
Development and application of a multimodal contrast agent for SPECT/CT hybrid imaging. Bioconjugate chemistry\| PubMed ID: 21851119	2011
Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis. Nature\| PubMed ID: 21983962	2011
Endothelial-derived angiocrine signals induce and sustain regenerative lung alveolarization. Cell\| PubMed ID: 22036563	2011
VEGF signaling inside vascular endothelial cells and beyond. Current opinion in cell biology\| PubMed ID: 22366328	2012
ALK1 signaling inhibits angiogenesis by cooperating with the Notch pathway. Developmental cell\| PubMed ID: 22421041	2012
Syndecan 4 regulates FGFR1 signaling in endothelial cells by directing macropinocytosis. Science signaling\| PubMed ID: 22569333	2012
Fibroblast growth factor signaling potentiates VE-cadherin stability at adherens junctions by regulating SHP2. PloS one\| PubMed ID: 22629427	2012
"On-target" cardiac effects of anticancer drugs: lessons from new biology. Journal of the American College of Cardiology\| PubMed ID: 22703925	2012
Syndecan 4 regulation of PDK1-dependent Akt activation. Cellular signalling\| PubMed ID: 22975683	2013
Fibroblast growth factor-2 is required for vasa vasorum plexus stability in hypercholesterolemic mice. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 22982464	2012
Profilin phosphorylation as a VEGFR effector in angiogenesis. Nature cell biology\| PubMed ID: 23033049	2012
Endothelial nuclear factor-κB-dependent regulation of arteriogenesis and branching. Circulation\| PubMed ID: 23091063	2012
Endothelial deletion of murine Jag1 leads to valve calcification and congenital heart defects associated with Alagille syndrome. Development (Cambridge, England)\| PubMed ID: 23095891	2012
FGF regulates TGF-Î² signaling and endothelial-to-mesenchymal transition via control of let-7 miRNA expression. Cell reports\| PubMed ID: 23200853	2012
Endothelial ERK signaling controls lymphatic fate specification. The Journal of clinical investigation\| PubMed ID: 23391722	2013
The syndecan-4/protein kinase Cα pathway mediates prostaglandin E2-induced extracellular regulated kinase (ERK) activation in endothelial cells and angiogenesis in vivo. The Journal of biological chemistry\| PubMed ID: 23525101	2013
Endothelial RAF1/ERK activation regulates arterial morphogenesis. Blood\| PubMed ID: 23529931	2013
Dll4-Notch signaling determines the formation of native arterial collateral networks and arterial function in mouse ischemia models. Development (Cambridge, England)\| PubMed ID: 23533173	2013
Lymphatic fate determination: playing RAF with ERK. Cell cycle (Georgetown, Tex.)\| PubMed ID: 23549166	2013
The neuropilin 1 cytoplasmic domain is required for VEGF-A-dependent arteriogenesis. Developmental cell\| PubMed ID: 23639442	2013
Effects of cell grafting on coronary remodeling after myocardial infarction. Journal of the American Heart Association\| PubMed ID: 23723253	2013
VEGFR2 trafficking: speed doesn't kill. Cell cycle (Georgetown, Tex.)\| PubMed ID: 23803732	2013
Endothelial cell-dependent regulation of arteriogenesis. Circulation research\| PubMed ID: 23897694	2013
Physiology. Lymphatics are in my veins. Science (New York, N.Y.)\| PubMed ID: 23929973	2013
Need glucose to sprout: local metabolic control of angiogenesis. EMBO molecular medicine\| PubMed ID: 23982994	2013
Endothelial signaling and the molecular basis of arteriovenous malformation. Cellular and molecular life sciences : CMLS\| PubMed ID: 24077895	2013
Transmembrane protein ESDN promotes endothelial VEGF signaling and regulates angiogenesis. The Journal of clinical investigation\| PubMed ID: 24177422	2013
Angiopoietin-2 secretion by endothelial cell exosomes: regulation by the phosphatidylinositol 3-kinase (PI3K)/Akt/endothelial nitric oxide synthase (eNOS) and syndecan-4/syntenin pathways. The Journal of biological chemistry\| PubMed ID: 24235146	2014
Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis. Nature\| PubMed ID: 24256728	2014
Inter-cellular exchange of cellular components via VE-cadherin-dependent trans-endocytosis. PloS one\| PubMed ID: 24603875	2014
Angiocrine factors deployed by tumor vascular niche induce B cell lymphoma invasiveness and chemoresistance. Cancer cell\| PubMed ID: 24651014	2014
The docking protein FRS2α is a critical regulator of VEGF receptors signaling. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24706887	2014
Receptor tyrosine kinases endocytosis in endothelium: biology and signaling. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 24925972	2014
Vasa vasorum in normal and diseased arteries. Circulation\| PubMed ID: 24934463	2014
Netrin-1 controls sympathetic arterial innervation. The Journal of clinical investigation\| PubMed ID: 24937433	2014
PTP1b is a physiologic regulator of vascular endothelial growth factor signaling in endothelial cells. Circulation\| PubMed ID: 24982127	2014
Flow-regulated lymphatic vasculature development and signaling. Vascular cell\| PubMed ID: 25053993	2014
Lymphatic fate specification: an ERK-controlled transcriptional program. Microvascular research\| PubMed ID: 25132472	2014
Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25136137	2014
Chemokine-coupled β2 integrin-induced macrophage Rac2-Myosin IIA interaction regulates VEGF-A mRNA stability and arteriogenesis. The Journal of experimental medicine\| PubMed ID: 25180062	2014
Fibroblast growth factor receptor 1 is a key inhibitor of TGFβ signaling in the endothelium. Science signaling\| PubMed ID: 25249657	2014
Fox(y) regulators of VEGF receptors. Circulation research\| PubMed ID: 25258399	2014
Up-regulation of thrombospondin-2 in Akt1-null mice contributes to compromised tissue repair due to abnormalities in fibroblast function. The Journal of biological chemistry\| PubMed ID: 25389299	2015
ELAVL1 regulates alternative splicing of eIF4E transporter to promote postnatal angiogenesis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25422430	2014
Molecular controls of lymphatic VEGFR3 signaling. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 25524775	2015
Endothelial cell metabolism in normal and diseased vasculature. Circulation research\| PubMed ID: 25814684	2015
Cardiomyopathy and Worsened Ischemic Heart Failure in SM22-α Cre-Mediated Neuropilin-1 Null Mice: Dysregulation of PGC1α and Mitochondrial Homeostasis. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 25882068	2015
Angiogenesis versus arteriogenesis: neuropilin 1 modulation of VEGF signaling. F1000prime reports\| PubMed ID: 25926977	2015
Molecular controls of arterial morphogenesis. Circulation research\| PubMed ID: 25953926	2015
When it is better to regress: dynamics of vascular pruning. PLoS biology\| PubMed ID: 25978860	2015
Endothelial miR-17∼92 cluster negatively regulates arteriogenesis via miRNA-19 repression of WNT signaling. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26417068	2015
Endothelial-to-mesenchymal transition drives atherosclerosis progression. The Journal of clinical investigation\| PubMed ID: 26517696	2015
When endothelial cells go rogue. EMBO molecular medicine\| PubMed ID: 26613939	2016
The expanding role of neuropilin: regulation of transforming growth factor-β and platelet-derived growth factor signaling in the vasculature. Current opinion in hematology\| PubMed ID: 26849476	2016
Smooth muscle FGF/TGFβ cross talk regulates atherosclerosis progression. EMBO molecular medicine\| PubMed ID: 27189169	2016
Sympathetic Innervation Promotes Arterial Fate by Enhancing Endothelial ERK Activity. Circulation research\| PubMed ID: 27354211	2016
Fibroblast growth factor (FGF) signaling regulates transforming growth factor beta (TGFβ)-dependent smooth muscle cell phenotype modulation. Scientific reports\| PubMed ID: 27634335	2016
Syndecan 4 controls lymphatic vasculature remodeling during mouse embryonic development. Development (Cambridge, England)\| PubMed ID: 27789626	2016
Modulation of VEGF receptor 2 signaling by protein phosphatases. Pharmacological research\| PubMed ID: 27888154	2017
The molecular basis of endothelial cell plasticity. Nature communications\| PubMed ID: 28181491	2017
Post-endocytic sorting of Plexin-D1 controls signal transduction and development of axonal and vascular circuits. Nature communications\| PubMed ID: 28224988	2017
FGF-dependent metabolic control of vascular development. Nature\| PubMed ID: 28467822	2017
SUMOylation Negatively Regulates Angiogenesis by Targeting Endothelial NOTCH Signaling. Circulation research\| PubMed ID: 28760777	2017
The Rab-effector protein RABEP2 regulates endosomal trafficking to mediate vascular endothelial growth factor receptor-2 (VEGFR2)-dependent signaling. The Journal of biological chemistry\| PubMed ID: 29425100	2018
Endothelial Cell Autonomous Role of Akt1: Regulation of Vascular Tone and Ischemia-Induced Arteriogenesis. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 29449333	2018
Reprogramming the Endocardium: Trials and Tribulations. Circulation research\| PubMed ID: 29599272	2018
Endothelial Metabolic Control of Lymphangiogenesis. BioEssays : news and reviews in molecular, cellular and developmental biology\| PubMed ID: 29750374	2018
Recent advances in understanding lymphangiogenesis and metabolism. F1000Research\| PubMed ID: 30079231	2018
Fibroblast growth factor-transforming growth factor beta dialogues, endothelial cell to mesenchymal transition, and atherosclerosis. Current opinion in lipidology\| PubMed ID: 30080704	2018
Lacteal junction zippering protects against diet-induced obesity. Science (New York, N.Y.)\| PubMed ID: 30093598	2018
SUMOylation of VEGFR2 regulates its intracellular trafficking and pathological angiogenesis. Nature communications\| PubMed ID: 30120232	2018
Metabolic Analysis of Lymphatic Endothelial Cells. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 30242770	2018
N-terminal syndecan-2 domain selectively enhances 6-O heparan sulfate chains sulfation and promotes VEGFA-dependent neovascularization. Nature communications\| PubMed ID: 30952866	2019
Publisher Correction: N-terminal syndecan-2 domain selectively enhances 6-O heparan sulfate chains sulfation and promotes VEGFA-dependent neovascularization. Nature communications\| PubMed ID: 31064993	2019
Endothelial ERK1/2 signaling maintains integrity of the quiescent endothelium. The Journal of experimental medicine\| PubMed ID: 31196980	2019
Author Correction: SUMOylation of VEGFR2 regulates its intracellular trafficking and pathological angiogenesis. Nature communications\| PubMed ID: 31417083	2019
Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis. Nature metabolism\| PubMed ID: 31572976	2019
FRS2α-dependent cell fate transition during endocardial cushion morphogenesis. Developmental biology\| PubMed ID: 31669335	2020
Isoform-Specific Roles of ERK1 and ERK2 in Arteriogenesis. Cells\| PubMed ID: 31877781	2019
Resilience, disease and the age of single cell science. Aging\| PubMed ID: 32039835	2020
Smooth Muscle Cell Reprogramming in Aortic Aneurysms. Cell stem cell\| PubMed ID: 32243809	2020
Endothelial-to-Mesenchymal Transition, Vascular Inflammation, and Atherosclerosis. Frontiers in cardiovascular medicine\| PubMed ID: 32478094	2020
phenotype projection of endothelial ERK1/2 signaling. Aging\| PubMed ID: 32530820	2020
The quiescent endothelium: signalling pathways regulating organ-specific endothelial normalcy. Nature reviews. Cardiology\| PubMed ID: 33627876	2021
Developmental Perspectives on Arterial Fate Specification. Frontiers in cell and developmental biology\| PubMed ID: 34249941	2021
Emerging roles of PLCγ1 in endothelial biology. Science signaling\| PubMed ID: 34344833	2021
Role of Venous Endothelial Cells in Developmental and Pathologic Angiogenesis. Circulation\| PubMed ID: 34474596	2021
Fibroblast growth factors: the keepers of endothelial normalcy. The Journal of clinical investigation\| PubMed ID: 34623324	2021
Identification of driver genes for critical forms of COVID-19 in a deeply phenotyped young patient cohort. Science translational medicine\| PubMed ID: 34698500	2022
MEKK3-TGFβ crosstalk regulates inward arterial remodeling. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 34911761	2021
Endothelium-derived lactate is required for pericyte function and blood-brain barrier maintenance. The EMBO journal\| PubMed ID: 35243676	2022
Flow goes forward and cells step backward: endothelial migration. Experimental & molecular medicine\| PubMed ID: 35701563	2022
FGFR1 SUMOylation coordinates endothelial angiogenic signaling in angiogenesis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 35733256	2022
BMPR1A Promotes ID2-ZEB1 Interaction to Suppress Excessive Endothelial to Mesenchymal Transition. Cardiovascular research\| PubMed ID: 36166408	2022