Michael W. Epperly

Affiliated with

Research Area

Biography

Michael W. Epperly has not added Biography.
If you are Michael W. Epperly and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 2	2022

Other Publications

Article	Year
Radioprotection of lung and esophagus by overexpression of the human manganese superoxide dismutase transgene. Military medicine\| PubMed ID: 11873523	2002
Manganese superoxide dismutase (SOD2) inhibits radiation-induced apoptosis by stabilization of the mitochondrial membrane. Radiation research\| PubMed ID: 11966323	2002
Prevention of radiation-induced oral cavity mucositis by plasmid/liposome delivery of the human manganese superoxide dismutase (SOD2) transgene. Radiation research\| PubMed ID: 12600239	2003
Bone marrow origin of myofibroblasts in irradiation pulmonary fibrosis. American journal of respiratory cell and molecular biology\| PubMed ID: 12649121	2003
Manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) intratracheal gene therapy reduction of irradiation-induced inflammatory cytokines does not protect orthotopic Lewis lung carcinoma... In vivo (Athens, Greece)\| PubMed ID: 12655784	2003
Overexpression of the transgene for manganese superoxide dismutase (MnSOD) in 32D cl 3 cells prevents apoptosis induction by TNF-alpha, IL-3 withdrawal, and ionizing radiation. Experimental hematology\| PubMed ID: 12829021	2003
Mitochondrial localization of superoxide dismutase is required for decreasing radiation-induced cellular damage. Radiation research\| PubMed ID: 14565825	2003
Correlation of ionizing irradiation-induced late pulmonary fibrosis with long-term bone marrow culture fibroblast progenitor cell biology in mice homozygous deletion recombinant negative for... In vivo (Athens, Greece)\| PubMed ID: 15011745	2004
Bone marrow origin of cells with capacity for homing and differentiation to esophageal squamous epithelium. Radiation research\| PubMed ID: 15333000	2004
Intraoral manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) radioprotective gene therapy decreases ionizing irradiation-induced murine mucosal cell cycling and apoptosis. In vivo (Athens, Greece)\| PubMed ID: 15369176	2004
Abrogation of head and neck squamous cell carcinoma growth by epidermal growth factor receptor ligand fused to pseudomonas exotoxin transforming growth factor alpha-PE38. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 15501988	2004
In vitro differentiation capacity of esophageal progenitor cells with capacity for homing and repopulation of the ionizing irradiation-damaged esophagus. In vivo (Athens, Greece)\| PubMed ID: 15646807	2004
Increased longevity of hematopoiesis in continuous bone marrow cultures and adipocytogenesis in marrow stromal cells derived from Smad3(-/-) mice. Experimental hematology\| PubMed ID: 15730859	2005
MnSOD-plasmid liposome gene therapy decreases ionizing irradiation-induced lipid peroxidation of the esophagus. In vivo (Athens, Greece)\| PubMed ID: 16277013	2005
Thalidomide radiosensitization of normal murine hematopoietic but not squamous cell carcinoma or multiple myeloma tumor cell lines. In vivo (Athens, Greece)\| PubMed ID: 16724666	2006
Increased radioresistance, g(2)/m checkpoint inhibition, and impaired migration of bone marrow stromal cell lines derived from Smad3(-/-) mice. Radiation research\| PubMed ID: 16802867	2006
Bone marrow from CD18-/- (MAC-1-/-) homozygous deletion recombinant negative mice demonstrates increased longevity in long-term bone marrow culture and decreased contribution to irradiation ... In vivo (Athens, Greece)\| PubMed ID: 16900771	2006
Reduced irradiation pulmonary fibrosis and stromal cell migration in Smad3-/- marrow chimeric mice. In vivo (Athens, Greece)\| PubMed ID: 17091762	2006
Increased longevity of hematopoiesis in continuous bone marrow cultures derived from NOS1 (nNOS, mtNOS) homozygous recombinant negative mice correlates with radioresistance of hematopoietic ... Experimental hematology\| PubMed ID: 17198882	2007
Effect of EGFR antagonists gefitinib (Iressa) and C225 (Cetuximab) on MnSOD-plasmid liposome transgene radiosensitization of a murine squamous cell carcinoma cell line. In vivo (Athens, Greece)\| PubMed ID: 17203769	2006
Effects of MnSOD-plasmid liposome gene therapy on antioxidant levels in irradiated murine oral cavity orthotopic tumors. Radiation research\| PubMed ID: 17316075	2007
Review. Antioxidant gene therapeutic approaches to normal tissue radioprotection and tumor radiosensitization. In vivo (Athens, Greece)\| PubMed ID: 17436562	2007
Overexpression of the MnSOD transgene product protects cryopreserved bone marrow hematopoietic progenitor cells from ionizing radiation. Radiation research\| PubMed ID: 17973554	2007
Radioprotection in vitro and in vivo by minicircle plasmid carrying the human manganese superoxide dismutase transgene. Human gene therapy\| PubMed ID: 18699723	2008
Regulation of the anaphase-promoting complex-separase cascade by transforming growth factor-beta modulates mitotic progression in bone marrow stromal cells. Molecular biology of the cell\| PubMed ID: 18843049	2008
Modulation of radiation-induced life shortening by systemic intravenous MnSOD-plasmid liposome gene therapy. Radiation research\| PubMed ID: 19024650	2008
Mitochondrial targeting of a catalase transgene product by plasmid liposomes increases radioresistance in vitro and in vivo. Radiation research\| PubMed ID: 19580494	2009
Investigation of the effects of aging on homologous recombination in long-term bone marrow cultures. In vivo (Athens, Greece)\| PubMed ID: 19779099	2009
The mitochondria-targeted nitroxide JP4-039 augments potentially lethal irradiation damage repair. In vivo (Athens, Greece)\| PubMed ID: 19779106	2009
Effectiveness of combined modality radiotherapy of orthotopic human squamous cell carcinomas in Nu/Nu mice using cetuximab, tirapazamine and MnSOD-plasmid liposome gene therapy. In vivo (Athens, Greece)\| PubMed ID: 20133969	2010
Screening of antimicrobial agents for in vitro radiation protection and mitigation capacity, including those used in supportive care regimens for bone marrow transplant recipients. In vivo (Athens, Greece)\| PubMed ID: 20133970	2010
Small molecule GS-nitroxide ameliorates ionizing irradiation-induced delay in bone wound healing in a novel murine model. In vivo (Athens, Greece)\| PubMed ID: 20668303	2010
Intraesophageal manganese superoxide dismutase-plasmid liposomes ameliorates novel total-body and thoracic radiation sensitivity of NOS1-/- mice. Radiation research\| PubMed ID: 20726721	2010
Effects of irradiating adult mdx mice before full-length dystrophin cDNA transfer on host anti-dystrophin immunity. Gene therapy\| PubMed ID: 20827278	2010
A phase I study of concurrent chemotherapy (paclitaxel and carboplatin) and thoracic radiotherapy with swallowed manganese superoxide dismutase plasmid liposome protection in patients with l... Human gene therapy\| PubMed ID: 20873987	2011
Intraesophageal administration of GS-nitroxide (JP4-039) protects against ionizing irradiation-induced esophagitis. In vivo (Athens, Greece)\| PubMed ID: 21164038	2010
Modulation of in utero total body irradiation induced newborn mouse growth retardation by maternal manganese superoxide dismutase-plasmid liposome (MnSOD-PL) gene therapy. Gene therapy\| PubMed ID: 21248791	2011
Antioxidant-chemoprevention diet ameliorates late effects of total-body irradiation and supplements radioprotection by MnSOD-plasmid liposome administration. Radiation research\| PubMed ID: 21466381	2011
Two strategies for the development of mitochondrion-targeted small molecule radiation damage mitigators. International journal of radiation oncology, biology, physics\| PubMed ID: 21493014	2011
Radiobiologic effects of GS-nitroxide (JP4-039) on the hematopoietic syndrome. In vivo (Athens, Greece)\| PubMed ID: 21576404	2011
The autophagy-inducing drug carbamazepine is a radiation protector and mitigator. International journal of radiation biology\| PubMed ID: 21728759	2011
The Use of 3,5,4'-Tri-O-acetylresveratrol as a Potential Pro-drug for Resveratrol Protects Mice from γ-Irradiation-Induced Death. ACS medicinal chemistry letters\| PubMed ID: 21826253	2011
GS-nitroxide (JP4-039)-mediated radioprotection of human Fanconi anemia cell lines. Radiation research\| PubMed ID: 21939290	2011
Amelioration of radiation esophagitis by orally administered p53/Mdm2/Mdm4 inhibitor (BEB55) or GS-nitroxide. In vivo (Athens, Greece)\| PubMed ID: 22021675	2011
Role of the esophageal vagus neural pathway in ionizing irradiation-induced seizures in nitric oxide synthase-1 homologous recombinant negative NOS1-/- mice. In vivo (Athens, Greece)\| PubMed ID: 22021678	2011
Repopulation of the irradiation damaged lung with bone marrow-derived cells. In vivo (Athens, Greece)\| PubMed ID: 22210711	2012
Dysregulated in vitro hematopoiesis, radiosensitivity, proliferation, and osteoblastogenesis with marrow from SAMP6 mice. Experimental hematology\| PubMed ID: 22326715	2012
Strategies for discovery of small molecule radiation protectors and radiation mitigators. Frontiers in oncology\| PubMed ID: 22655254	2011
The zebrafish--Danio rerio--is a useful model for measuring the effects of small-molecule mitigators of late effects of ionizing irradiation. In vivo (Athens, Greece)\| PubMed ID: 23160669	2012
Effects of thoracic irradiation on pulmonary endothelial compared to alveolar type-II cells in fibrosis-prone C57BL/6NTac mice. In vivo (Athens, Greece)\| PubMed ID: 23606683	2013
Synthesis of analogs of the radiation mitigator JP4-039 and visualization of BODIPY derivatives in mitochondria. Organic & biomolecular chemistry\| PubMed ID: 23715589	2013
Conditional radioresistance of Tet-inducible manganese superoxide dismutase bone marrow stromal cell lines. Radiation research\| PubMed ID: 23862693	2013
Evaluation of potential ionizing irradiation protectors and mitigators using clonogenic survival of human umbilical cord blood hematopoietic progenitor cells. Experimental hematology\| PubMed ID: 23933481	2013
Radioresistance of bone marrow stromal and hematopoietic progenitor cell lines derived from Nrf2-/- homozygous deletion recombinant-negative mice. In vivo (Athens, Greece)\| PubMed ID: 23988890	2013
Amelioration of radiation-induced pulmonary fibrosis by a water-soluble bifunctional sulfoxide radiation mitigator (MMS350). Radiation research\| PubMed ID: 24125487	2013
Radiologic differences between bone marrow stromal and hematopoietic progenitor cell lines from Fanconi Anemia (Fancd2(-/-)) mice. Radiation research\| PubMed ID: 24397476	2014
Improved survival of mice after total body irradiation with 10 MV photon, 2400 MU/min SRS beam. In vivo (Athens, Greece)\| PubMed ID: 24425830	2014
Can Radiosensitivity Associated with Defects in DNA Repair be Overcome by Mitochondrial-Targeted Antioxidant Radioprotectors. Frontiers in oncology\| PubMed ID: 24596683	2014
Differences in irradiated lung gene transcription between fibrosis-prone C57BL/6NHsd and fibrosis-resistant C3H/HeNHsd mice. In vivo (Athens, Greece)\| PubMed ID: 24632969	2014
Amelioration of Radiation-Induced Oral Cavity Mucositis and Distant Bone Marrow Suppression in Fanconi Anemia Fancd2(-/-) (FVB/N) Mice by Intraoral GS-Nitroxide JP4-039. Radiation research\| PubMed ID: 24932534	2014
Improved longevity of hematopoiesis in long-term bone marrow cultures and reduced irradiation-induced pulmonary fibrosis in Toll-like receptor-4 deletion recombinant-negative mice. In vivo (Athens, Greece)\| PubMed ID: 24982208	2014
Increased hematopoiesis in long-term bone marrow cultures and reduced irradiation-induced pulmonary fibrosis in Von Willebrand factor homologous deletion recombinant mice. In vivo (Athens, Greece)\| PubMed ID: 24982209	2014
Effects of the bifunctional sulfoxide MMS350, a radiation mitigator, on hematopoiesis in long-term bone marrow cultures and on radioresistance of marrow stromal cell lines. In vivo (Athens, Greece)\| PubMed ID: 24982210	2014
Improved hematopoiesis in GS-nitroxide (JP4-039)-treated mouse long-term bone marrow cultures and radioresistance of derived bone marrow stromal cell lines. In vivo (Athens, Greece)\| PubMed ID: 25189880	2014
Organ-specific responses of total body irradiated doxycycline-inducible manganese superoxide dismutase Tet/Tet mice. In vivo (Athens, Greece)\| PubMed ID: 25398796	2014
Pulmonary receptor for advanced glycation end-products promotes asthma pathogenesis through IL-33 and accumulation of group 2 innate lymphoid cells. The Journal of allergy and clinical immunology\| PubMed ID: 25930197	2015
The HSP90 Inhibitor Ganetespib Radiosensitizes Human Lung Adenocarcinoma Cells. Cancers\| PubMed ID: 26010604	2015
Radioresistant human lung adenocarcinoma cells that survived multiple fractions of ionizing radiation are sensitive to HSP90 inhibition. Oncotarget\| PubMed ID: 26517240	2015
Intraoral Mitochondrial-Targeted GS-Nitroxide, JP4-039, Radioprotects Normal Tissue in Tumor-Bearing Radiosensitive Fancd2(-/-) (C57BL/6) Mice. Radiation research\| PubMed ID: 26789701	2016
Evolution of malignant plasmacytoma cell lines from K14E7 Fancd2-/- mouse long-term bone marrow cultures. Oncotarget\| PubMed ID: 27637088	2016
Effectiveness of Analogs of the GS-Nitroxide, JP4-039, as Total Body Irradiation Mitigators. In vivo (Athens, Greece)\| PubMed ID: 28064218	2017
Induction of TGF-β by Irradiation or Chemotherapy in Fanconi Anemia (FA) Mouse Bone Marrow Is Modulated by Small Molecule Radiation Mitigators JP4-039 and MMS350. In vivo (Athens, Greece)\| PubMed ID: 28358695	2017
Reduced Competitive Repopulation Capacity of Multipotential Hematopoietic Stem Cells in the Bone Marrow of Friend Virus-infected Fv2-resistant Mice. In vivo (Athens, Greece)\| PubMed ID: 28438857	2017
Liquid chromatography-tandem mass spectrometric assay for the quantitation of the novel radiation protective agent and radiation mitigator JP4-039 in murine plasma. Journal of pharmaceutical and biomedical analysis\| PubMed ID: 29245086	2018
Amelioration of Head and Neck Radiation-Induced Mucositis and Distant Marrow Suppression in Fanca and Fancg Mice by Intraoral Administration of GS-Nitroxide (JP4-039). Radiation research\| PubMed ID: 29584588	2018
Development of tensile strength methodology for murine skin wound healing. MethodsX\| PubMed ID: 30050753	2018
Synthesis and Evaluation of a Mitochondria-Targeting Poly(ADP-ribose) Polymerase-1 Inhibitor. ACS chemical biology\| PubMed ID: 30184433	2018
Adipose-Derived Stem Cell Therapy Ameliorates Ionizing Irradiation Fibrosis via Hepatocyte Growth Factor-Mediated Transforming Growth Factor-β Downregulation and Recruitment of Bone Marrow C... Stem cells (Dayton, Ohio)\| PubMed ID: 30861238	2019
Allogeneic adipose-derived stem cells mitigate acute radiation syndrome by the rescue of damaged bone marrow cells from apoptosis. Stem cells translational medicine\| PubMed ID: 33724714	2021