Erwin London

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2025

Other Publications

Article	Year
Using a novel dual fluorescence quenching assay for measurement of tryptophan depth within lipid bilayers to determine hydrophobic alpha-helix locations within membranes. Biochemistry\| PubMed ID: 12641458	2003
Cumulative effects of amino acid substitutions and hydrophobic mismatch upon the transmembrane stability and conformation of hydrophobic alpha-helices. Biochemistry\| PubMed ID: 12641459	2003
Ceramide selectively displaces cholesterol from ordered lipid domains (rafts): implications for lipid raft structure and function. The Journal of biological chemistry\| PubMed ID: 14699154	2004
Relationship between sterol/steroid structure and participation in ordered lipid domains (lipid rafts): implications for lipid raft structure and function. Biochemistry\| PubMed ID: 14744146	2004
Position and ionization state of Asp in the core of membrane-inserted alpha helices control both the equilibrium between transmembrane and nontransmembrane helix topography and transmembrane... Biochemistry\| PubMed ID: 15236588	2004
Topography of diphtheria toxin A chain inserted into lipid vesicles. Biochemistry\| PubMed ID: 15697244	2005
Palmitoylation and intracellular domain interactions both contribute to raft targeting of linker for activation of T cells. The Journal of biological chemistry\| PubMed ID: 15753089	2005
Behavior of diphtheria toxin T domain containing substitutions that block normal membrane insertion at Pro345 and Leu307: control of deep membrane insertion and coupling between deep inserti... Biochemistry\| PubMed ID: 15766279	2005
How principles of domain formation in model membranes may explain ambiguities concerning lipid raft formation in cells. Biochimica et biophysica acta\| PubMed ID: 16225940	2005
Cholesterol precursors stabilize ordinary and ceramide-rich ordered lipid domains (lipid rafts) to different degrees. Implications for the Bloch hypothesis and sterol biosynthesis disorders. The Journal of biological chemistry\| PubMed ID: 16735517	2006
Topography of the hydrophilic helices of membrane-inserted diphtheria toxin T domain: TH1-TH3 as a hydrophilic tether. Biochemistry\| PubMed ID: 16800637	2006
An amino acid "transmembrane tendency" scale that approaches the theoretical limit to accuracy for prediction of transmembrane helices: relationship to biological hydrophobicity. Protein science : a publication of the Protein Society\| PubMed ID: 16877712	2006
Membrane topography of the hydrophobic anchor sequence of poliovirus 3A and 3AB proteins and the functional effect of 3A/3AB membrane association upon RNA replication. Biochemistry\| PubMed ID: 17417822	2007
The phenyltetraene lysophospholipid analog PTE-ET-18-OMe as a fluorescent anisotropy probe of liquid ordered membrane domains (lipid rafts) and ceramide-rich membrane domains. Biochimica et biophysica acta\| PubMed ID: 17573036	2007
Effect of ceramide N-acyl chain and polar headgroup structure on the properties of ordered lipid domains (lipid rafts). Biochimica et biophysica acta\| PubMed ID: 17574203	2007
Using model membrane-inserted hydrophobic helices to study the equilibrium between transmembrane and nontransmembrane states. The Journal of general physiology\| PubMed ID: 17635963	2007
Effect of the structure of lipids favoring disordered domain formation on the stability of cholesterol-containing ordered domains (lipid rafts): identification of multiple raft-stabilization... Biophysical journal\| PubMed ID: 17766350	2007
Effect of sequence hydrophobicity and bilayer width upon the minimum length required for the formation of transmembrane helices in membranes. Journal of molecular biology\| PubMed ID: 17950311	2007
The control of transmembrane helix transverse position in membranes by hydrophilic residues. Journal of molecular biology\| PubMed ID: 17997412	2007
How interaction of perfringolysin O with membranes is controlled by sterol structure, lipid structure, and physiological low pH: insights into the origin of perfringolysin O-lipid raft inter... The Journal of biological chemistry\| PubMed ID: 18089559	2008
Detecting ordered domain formation (lipid rafts) in model membranes using Tempo. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 18214372	2007
Behavior of the deeply inserted helices in diphtheria toxin T domain: helices 5, 8, and 9 interact strongly and promote pore formation, while helices 6/7 limit pore formation. Biochemistry\| PubMed ID: 18355037	2008
Effect of lipid composition on the topography of membrane-associated hydrophobic helices: stabilization of transmembrane topography by anionic lipids. Journal of molecular biology\| PubMed ID: 18479706	2008
Preparation and properties of asymmetric vesicles that mimic cell membranes: effect upon lipid raft formation and transmembrane helix orientation. The Journal of biological chemistry\| PubMed ID: 19129198	2009
Strong correlation between statistical transmembrane tendency and experimental hydrophobicity scales for identification of transmembrane helices. The Journal of membrane biology\| PubMed ID: 19521654	2009
The membrane topography of the diphtheria toxin T domain linked to the a chain reveals a transient transmembrane hairpin and potential translocation mechanisms. Biochemistry\| PubMed ID: 19780588	2009
The effect of hydrophilic substitutions and anionic lipids upon the transverse positioning of the transmembrane helix of the ErbB2 (neu) protein incorporated into model membrane vesicles. Journal of molecular biology\| PubMed ID: 19931543	2010
Low pH-induced pore formation by the T domain of botulinum toxin type A is dependent upon NaCl concentration. The Journal of membrane biology\| PubMed ID: 20711775	2010
Cholesterol lipids of Borrelia burgdorferi form lipid rafts and are required for the bactericidal activity of a complement-independent antibody. Cell host & microbe\| PubMed ID: 20951967	2010
Perfringolysin O association with ordered lipid domains: implications for transmembrane protein raft affinity. Biophysical journal\| PubMed ID: 21081073	2010
Preparation and properties of asymmetric large unilamellar vesicles: interleaflet coupling in asymmetric vesicles is dependent on temperature but not curvature. Biophysical journal\| PubMed ID: 21641312	2011
Measurement of lipid nanodomain (raft) formation and size in sphingomyelin/POPC/cholesterol vesicles shows TX-100 and transmembrane helices increase domain size by coalescing preexisting nan... Biophysical journal\| PubMed ID: 22098740	2011
Anandamide externally added to lipid vesicles containing trapped fatty acid amide hydrolase (FAAH) is readily hydrolyzed in a sterol-modulated fashion. ACS chemical neuroscience\| PubMed ID: 22860204	2012
The dependence of lipid asymmetry upon phosphatidylcholine acyl chain structure. Journal of lipid research\| PubMed ID: 23093551	2013
Altering hydrophobic sequence lengths shows that hydrophobic mismatch controls affinity for ordered lipid domains (rafts) in the multitransmembrane strand protein perfringolysin O. The Journal of biological chemistry\| PubMed ID: 23150664	2013
Lipid exchange between Borrelia burgdorferi and host cells. PLoS pathogens\| PubMed ID: 23326230	2013
Sphingolipids and membrane domains: recent advances. Handbook of experimental pharmacology\| PubMed ID: 23579448	2013
Proving lipid rafts exist: membrane domains in the prokaryote Borrelia burgdorferi have the same properties as eukaryotic lipid rafts. PLoS pathogens\| PubMed ID: 23696733	2013
Mapping peptide thiol accessibility in membranes using a quaternary ammonium isotope-coded mass tag (ICMT). Bioconjugate chemistry\| PubMed ID: 23725486	2013
The dependence of lipid asymmetry upon polar headgroup structure. Journal of lipid research\| PubMed ID: 24101657	2013
Effect of cyclodextrin and membrane lipid structure upon cyclodextrin-lipid interaction. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 24175704	2013
Transmembrane protein (perfringolysin o) association with ordered membrane domains (rafts) depends upon the raft-associating properties of protein-bound sterol. Biophysical journal\| PubMed ID: 24359745	2013
The influence of natural lipid asymmetry upon the conformation of a membrane-inserted protein (perfringolysin O). The Journal of biological chemistry\| PubMed ID: 24398685	2014
Preparation of artificial plasma membrane mimicking vesicles with lipid asymmetry. PloS one\| PubMed ID: 24489974	2014
Selective association of outer surface lipoproteins with the lipid rafts of Borrelia burgdorferi. mBio\| PubMed ID: 24618252	2014
Using Sterol Substitution to Probe the Role of Membrane Domains in Membrane Functions. Lipids\| PubMed ID: 25804641	2015
Decreasing Transmembrane Segment Length Greatly Decreases Perfringolysin O Pore Size. The Journal of membrane biology\| PubMed ID: 25850715	2015
Ordered raft domains induced by outer leaflet sphingomyelin in cholesterol-rich asymmetric vesicles. Biophysical journal\| PubMed ID: 25954879	2015
Membrane fusion: A new role for lipid domains? Nature chemical biology\| PubMed ID: 25978994	2015
Raft-like membrane domains in pathogenic microorganisms. Current topics in membranes\| PubMed ID: 26015285	2015
Notch-modifying xylosyltransferase structures support an SNi-like retaining mechanism. Nature chemical biology\| PubMed ID: 26414444	2015
The Effect of Membrane Lipid Composition on the Formation of Lipid Ultrananodomains. Biophysical journal\| PubMed ID: 26488654	2015
Cholesterol lipids and cholesterol-containing lipid rafts in bacteria. Chemistry and physics of lipids\| PubMed ID: 26964703	2016
Subnanometer Structure of an Asymmetric Model Membrane: Interleaflet Coupling Influences Domain Properties. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 27128636	2016
New Insights into How Cholesterol and Unsaturation Control Lipid Domain Formation. Biophysical journal\| PubMed ID: 27508431	2016
Highly Hydrophilic Segments Attached to Hydrophobic Peptides Translocate Rapidly across Membranes. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 27649909	2016
Efficient replacement of plasma membrane outer leaflet phospholipids and sphingolipids in cells with exogenous lipids. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27872310	2016
Ordered Membrane Domain-Forming Properties of the Lipids of Borrelia burgdorferi. Biophysical journal\| PubMed ID: 28002743	2016
Islet Amyloid Polypeptide Membrane Interactions: Effects of Membrane Composition. Biochemistry\| PubMed ID: 28054763	2017
The effect of sterol structure upon clathrin-mediated and clathrin-independent endocytosis. Journal of cell science\| PubMed ID: 28655854	2017
Changes in glucosylceramide structure affect virulence and membrane biophysical properties of Cryptococcus neoformans. Biochimica et biophysica acta. Biomembranes\| PubMed ID: 28865794	2017
Analysis of Lipids and Lipid Rafts in Borrelia. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 29032537	2018
Effects of host cell sterol composition upon internalization of and clustered β1 integrin. The Journal of biological chemistry\| PubMed ID: 29197826	2018
Sterol Structure Strongly Modulates Membrane-Islet Amyloid Polypeptide Interactions. Biochemistry\| PubMed ID: 29373018	2018
Lipid rafts can form in the inner and outer membranes of Borrelia burgdorferi and have different properties and associated proteins. Molecular microbiology\| PubMed ID: 29377398	2018
Lipid Structure and Composition Control Consequences of Interleaflet Coupling in Asymmetric Vesicles. Biophysical journal\| PubMed ID: 30082033	2018
Preparation of asymmetric phospholipid vesicles for use as cell membrane models. Nature protocols\| PubMed ID: 30190552	2018
Sterol structure dependence of insulin receptor and insulin-like growth factor 1 receptor activation. Biochimica et biophysica acta. Biomembranes\| PubMed ID: 30682326	2019
Effect of sterol structure on ordered membrane domain (raft) stability in symmetric and asymmetric vesicles. Biochimica et biophysica acta. Biomembranes\| PubMed ID: 30904407	2019
Analyzing Transmembrane Protein and Hydrophobic Helix Topography by Dual Fluorescence Quenching. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 31218625	2019
Membrane Structure-Function Insights from Asymmetric Lipid Vesicles. Accounts of chemical research\| PubMed ID: 31386337	2019
Helicobacter pylori lipids can form ordered membrane domains (rafts). Biochimica et biophysica acta. Biomembranes\| PubMed ID: 31449801	2019
Kiss and Run Asymmetric Vesicles to Investigate Coupling. Biophysical journal\| PubMed ID: 31477242	2019
Replacing plasma membrane outer leaflet lipids with exogenous lipid without damaging membrane integrity. PloS one\| PubMed ID: 31589646	2019
Nanodomains can persist at physiologic temperature in plasma membrane vesicles and be modulated by altering cell lipids. Journal of lipid research\| PubMed ID: 31964764	2020
Induction of Ordered Lipid Raft Domain Formation by Loss of Lipid Asymmetry. Biophysical journal\| PubMed ID: 32710822	2020
Sphingomyelins and ent-Sphingomyelins Form Homophilic Nano-Subdomains within Liquid Ordered Domains. Biophysical journal\| PubMed ID: 32710823	2020
Preparation and Drug Entrapment Properties of Asymmetric Liposomes Containing Cationic and Anionic Lipids. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 33070610	2020
Preparation and utility of asymmetric lipid vesicles for studies of perfringolysin O-lipid interactions. Methods in enzymology\| PubMed ID: 33712189	2021
The Fluorescent Dye 1,6-Diphenyl-1,3,5-hexatriene Binds to Amyloid Fibrils Formed by Human Amylin and Provides a New Probe of Amylin Amyloid Kinetics. Biochemistry\| PubMed ID: 34128641	2021
Phospholipid exchange shows insulin receptor activity is supported by both the propensity to form wide bilayers and ordered raft domains. The Journal of biological chemistry\| PubMed ID: 34324831	2021
Using cyclodextrin-induced lipid substitution to study membrane lipid and ordered membrane domain (raft) function in cells. Biochimica et biophysica acta. Biomembranes\| PubMed ID: 34534531	2022
Preparation of Asymmetric Vesicles with Trapped CsCl Avoids Osmotic Imbalance, Non-Physiological External Solutions, and Minimizes Leakage. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 34550698	2021
Cholesterol and sphingomyelin are critical for Fcγ receptor-mediated phagocytosis of Cryptococcus neoformans by macrophages. The Journal of biological chemistry\| PubMed ID: 34793834	2021
Loss of plasma membrane lipid asymmetry can induce ordered domain (raft) formation. Journal of lipid research\| PubMed ID: 34843684	2022
Transbilayer Coupling of Lipids in Cells Investigated by Imaging Fluorescence Correlation Spectroscopy. The journal of physical chemistry. B\| PubMed ID: 35294838	2022
Molecular substructure of the liquid-ordered phase formed by sphingomyelin and cholesterol: sphingomyelin clusters forming nano-subdomains are a characteristic feature. Biophysical reviews\| PubMed ID: 35791389	2022
Ordered Domain (Raft) Formation in Asymmetric Vesicles and Its Induction upon Loss of Lipid Asymmetry in Artificial and Natural Membranes. Membranes\| PubMed ID: 36135889	2022
Impact of Ca on membrane catalyzed IAPP amyloid formation and IAPP induced vesicle leakage. Biochimica et biophysica acta. Biomembranes\| PubMed ID: 37121365	2023
Lipid-driven interleaflet coupling of plasma membrane order regulates FcεRI signaling in mast cells. Biophysical journal\| PubMed ID: 37533258	2024
Inner leaflet cationic lipid increases nucleic acid loading independently of outer leaflet lipid charge in asymmetric liposomes. Methods (San Diego, Calif.)\| PubMed ID: 37683900	2023
MαCD-based plasma membrane outer leaflet lipid exchange in mammalian cells to study insulin receptor activity. Methods in enzymology\| PubMed ID: 38971611	2024