transmesenteric-laparoscopic-pyeloplasty-trendelenburg-position-for

Transmesenteric Laparoscopic Pyeloplasty in Trendelenburg Position for Horseshoe Kidney with Hydronephrosis

Due to anomalous anatomy, pyeloplasty with a horseshoe kidney (HSK) presents a technical challenge. Previously, we reported a technique of intraperitoneal ...

clinical-efficacy-tissue-bone-homeostasis-manipulation-on-soft-tissue

Clinical Efficacy of Tissue-Bone Homeostasis Manipulation on Soft Tissue Balance and Function in Knee Osteoarthritis

Knee osteoarthritis (KOA) is characterized by progressive joint degeneration and biomechanical imbalance of periarticular soft tissues, leading to pain ...

To study the expression and significance of granulocyte-macrophage colony-stimulating factor (GM-CSF) receptors in human prostate cancer.

[Expression and significance of granulocyte-macrophage colony-stimulating factor receptors in human prostate cancer].

To investigate the phosphorylation intensity of MAPK pathway molecular Erk1/2 and the proliferation of prostate cancer cell line PC-3M.

[Role of MAPK signal transduction pathway phosphorylation induced by granulocyte-macrophage-colony stimulating factor in the proliferation of hormone-independent prostate cancer].

Single-cell sequencing technologies have noteworthily improved our understanding of the genetic map and molecular characteristics of bladder cancer (BC). Here we identify CD39 as a potential therapeutic target for BC via single-cell transcriptome analysis. In a subcutaneous tumor model and orthotopic bladder cancer model, inhibition of CD39 (CD39i) by sodium polyoxotungstate is able to limit the growth of BC and improve the overall survival of tumor-bearing mice. Via single cell RNA sequencing, we find that CD39i increase the intratumor NK cells, conventional type 1 dendritic cells (cDC1) and CD8 + T cells and decrease the Treg abundance. The antitumor effect and reprogramming of the tumor microenvironment are blockaded in both the NK cells depletion model and the cDC1-deficient Batf3 model. In addition, a significant synergistic effect is observed between CD39i and cisplatin, but the CD39i + anti-PD-L1 (or anti-PD1) strategy does not show any synergistic effects in the BC model. Our results confirm that CD39 is a potential target for the immune therapy of BC.

Single cell sequencing reveals that CD39 inhibition mediates changes to the tumor microenvironment.

About 10-20% of patients with bladder cancer (BC) progress to muscle-invasive diseases, of which the underlying key molecular events have yet to be addressed.

PABPN1 regulates mRNA alternative polyadenylation to inhibit bladder cancer progression.

The crosstalk between genomic alterations and metabolic dysregulation in bladder cancer is largely unknown. A deep understanding of the interactions between cancer drivers and cancer metabolic changes will provide novel opportunities for targeted therapeutic strategies.

Multi-omics analysis reveals critical metabolic regulators in bladder cancer.

To evaluate the safety and feasibility of intraperitoneal laparoscopic surgery in Trendelenburg position (ILSTP) for pyelolithotomy, pyeloplasty, and heminephrectomy in patients with horseshoe kidneys (HSKs).

Intraperitoneal laparoscopic technique in trendelenburg position: an effective surgical method for pyelolithotomy, pyeloplasty, and heminephrectomy in patients with horseshoe kidneys.

Zinner syndrome is a rare congenital malformation of the male genitourinary system, characterized by a triad: seminal vesicle cyst, unilateral renal agenesis, and ipsilateral ejaculatory duct obstruction. The etiology of this uncommon disease remains largely elusive; however, genetic mutations may contribute to its development. In this report, we present a case of symptomatic Zinner syndrome that was surgically treated, alongside an investigation into the potential genetic basis of the syndrome via whole exome sequencing.

Zinner syndrome: report of a case and whole exome sequencing.

Zinner syndrome (ZS) is a rare anomaly of the Wolffian duct. Here, we present a case of seminal vesiculectomy and ipsilateral nephroureterectomy using laparoscopic surgery in a modified supine position, which was performed in a 30-year-old male patient with ZS. To our knowledge, this is the first report to describe the feasible use of this approach to remove the seminal vesicle and ipsilateral atrophic kidney in a single session.

ArticleTotal : 2	Year
Publication title	2025
Publication title	2026

Article	Year
[Expression and significance of granulocyte-macrophage colony-stimulating factor receptors in human prostate cancer]. Zhonghua nan ke xue = National journal of andrology\| PubMed ID: 15497703	2004
[Role of MAPK signal transduction pathway phosphorylation induced by granulocyte-macrophage-colony stimulating factor in the proliferation of hormone-independent prostate cancer]. Zhonghua nan ke xue = National journal of andrology\| PubMed ID: 17121012	2006
Single cell sequencing reveals that CD39 inhibition mediates changes to the tumor microenvironment. Nature communications\| PubMed ID: 36347860	2022
PABPN1 regulates mRNA alternative polyadenylation to inhibit bladder cancer progression. Cell & bioscience\| PubMed ID: 36879298	2023
Multi-omics analysis reveals critical metabolic regulators in bladder cancer. International urology and nephrology\| PubMed ID: 37882969	2024
Intraperitoneal laparoscopic technique in trendelenburg position: an effective surgical method for pyelolithotomy, pyeloplasty, and heminephrectomy in patients with horseshoe kidneys. BMC urology\| PubMed ID: 39468533	2024
Zinner syndrome: report of a case and whole exome sequencing. Basic and clinical andrology\| PubMed ID: 40069600	2025
Intraperitoneal Laparoscopic Seminal Vesiculectomy and Ipsilateral Nephroureterectomy in Modified Supine Position for Treatment of Zinner's Syndrome. Asian journal of endoscopic surgery\| PubMed ID: 40302168	2025

Zhaohui Chen

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