network-pharmacological-analysis-tcm-formulae-based-on-syndrome

Network Pharmacological Analysis of TCM Formulae Based on the Syndrome Ontology and Multidimensional Quantitative Association Computing Platform

Current network pharmacology methods for TCM formulae predict potential active ingredients and mechanisms of action for specific diseases by constructing ...

l-carnitine infusion has been proven to reduce fasting-induced fatigue and hunger in patients with metabolic syndrome in our former study. However, the association between l-carnitine and clinical outcomes of fasting therapy is yet to be investigated. In this study, data from 192 patients who finished fasting therapy from September 2008 to July 2018 were reviewed, among which 142 patients received l-carnitine infusion in fasting regimen. Propensity matching was used to overcome retrospective bias. Patients' anthropometric measurements and metabolic markers were evaluated. After propensity matching, 40 patients were included in each group. Weight (-4.05 ± 1.65 kg vs -3.25 ± 1.68 kg, P = 0.031) and BMI (-1.51±0.61 kg/m vs -1.20 ± 0.62 kg/m, P = 0.036) decreased in both groups, but significantly more in l-carnitine group, while diastolic blood pressure (-1.67±9.82 mmHg vs -6.21±8.83 mmHg, P = 0.043) and triglycerides (-0.18±0.63 mmol/L vs -1.05±1.70 mmol/L, P = 0.007) decreased significantly more in non-l-carnitine group compared between groups, blood glucose did not differ significantly between groups. l-carnitine can boost the positive effects of fasting therapy on weight loss and maintain the stability of blood pressure.

L-carnitine ameliorated weight loss in fasting therapy: A propensity score-matched study.

Caloric restriction (CR) has become increasingly attractive in the treatment of type 2 diabetes mellitus (T2DM) because of the increasingly common high-calorie diet and sedentary lifestyle. This study aimed to evaluate the role of CR in T2DM treatment and further explore its potential molecular mechanisms.

Article	Year
L-carnitine ameliorated weight loss in fasting therapy: A propensity score-matched study. Complementary therapies in medicine\| PubMed ID: 31126550	2019
Protective effects of calorie restriction on insulin resistance and islet function in STZ-induced type 2 diabetes rats. Nutrition & metabolism\| PubMed ID: 33952301	2021

Li Hui

Biography

JoVE Journal Publications

Other Publications