William C. Mobley

Affiliated with

Research Area

Biography

William C. Mobley has not added Biography.
If you are William C. Mobley and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 24	2014
Publication title Cited by 37	2014

Other Publications

Article	Year
Traffic at the intersection of neurotrophic factor signaling and neurodegeneration. Trends in neurosciences\| PubMed ID: 12536130	2003
NGF signaling in sensory neurons: evidence that early endosomes carry NGF retrograde signals. Neuron\| PubMed ID: 12848933	2003
Trafficking the NGF signal: implications for normal and degenerating neurons. Progress in brain research\| PubMed ID: 14699953	2004
Signaling endosome hypothesis: A cellular mechanism for long distance communication. Journal of neurobiology\| PubMed ID: 14704953	2004
Going the distance, or not, with neurotrophin signals. Cell\| PubMed ID: 15260984	2004
Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 15371516	2004
Late onset neurodegeneration in the Cln3-/- mouse model of juvenile neuronal ceroid lipofuscinosis is preceded by low level glial activation. Brain research\| PubMed ID: 15374749	2004
An AUPN/ANA survey of department leader opinions on the health of US academic neurology. Neurology\| PubMed ID: 15505148	2004
Synaptic structural abnormalities in the Ts65Dn mouse model of Down Syndrome. The Journal of comparative neurology\| PubMed ID: 15515178	2004
Long-distance retrograde neurotrophic signaling. Current opinion in neurobiology\| PubMed ID: 15721743	2005
Identification and characterization of a new Down syndrome model, Ts[Rb(12.1716)]2Cje, resulting from a spontaneous Robertsonian fusion between T(171)65Dn and mouse chromosome 12. Mammalian genome : official journal of the International Mammalian Genome Society\| PubMed ID: 15859352	2005
TrkB binds and tyrosine-phosphorylates Tiam1, leading to activation of Rac1 and induction of changes in cellular morphology. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16801538	2006
Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration. Neuron\| PubMed ID: 16815330	2006
Retrolinkin, a membrane protein, plays an important role in retrograde axonal transport. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17287360	2007
Synaptic and cognitive abnormalities in mouse models of Down syndrome: exploring genotype-phenotype relationships. The Journal of comparative neurology\| PubMed ID: 17663443	2007
One at a time, live tracking of NGF axonal transport using quantum dots. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17698956	2007
A functional dynein-microtubule network is required for NGF signaling through the Rap1/MAPK pathway. Traffic (Copenhagen, Denmark)\| PubMed ID: 17822405	2007
Using mouse models to explore genotype-phenotype relationship in Down syndrome. Mental retardation and developmental disabilities research reviews\| PubMed ID: 17910089	2007
Membrane targeting by APPL1 and APPL2: dynamic scaffolds that oligomerize and bind phosphoinositides. Traffic (Copenhagen, Denmark)\| PubMed ID: 18034774	2008
Sleep and EEG features in genetic models of Down syndrome. Neurobiology of disease\| PubMed ID: 18282758	2008
Comparative study of brain morphology in Mecp2 mutant mouse models of Rett syndrome. The Journal of comparative neurology\| PubMed ID: 18306326	2008
Review of the toxicology of chlorpyrifos with an emphasis on human exposure and neurodevelopment. Critical reviews in toxicology\| PubMed ID: 18726789	2008
Endophilin B1 as a novel regulator of nerve growth factor/ TrkA trafficking and neurite outgrowth. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 18768694	2008
The coming of age of axonal neurotrophin signaling endosomes. Journal of proteomics\| PubMed ID: 19028611	2009
Excitatory-inhibitory relationship in the fascia dentata in the Ts65Dn mouse model of Down syndrome. The Journal of comparative neurology\| PubMed ID: 19034952	2009
Evidence for both neuronal cell autonomous and nonautonomous effects of methyl-CpG-binding protein 2 in the cerebral cortex of female mice with Mecp2 mutation. Neurobiology of disease\| PubMed ID: 19167498	2009
Widespread changes in dendritic and axonal morphology in Mecp2-mutant mouse models of Rett syndrome: evidence for disruption of neuronal networks. The Journal of comparative neurology\| PubMed ID: 19296534	2009
The "Down syndrome critical region" is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19420260	2009
The 50th anniversary of the discovery of trisomy 21: the past, present, and future of research and treatment of Down syndrome. Genetics in medicine : official journal of the American College of Medical Genetics\| PubMed ID: 19636252	2009
Deficiencies in the region syntenic to human 21q22.3 cause cognitive deficits in mice. Mammalian genome : official journal of the International Mammalian Genome Society\| PubMed ID: 20512340	2010
Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease. Neuron\| PubMed ID: 20826309	2010
Effects of individual segmental trisomies of human chromosome 21 syntenic regions on hippocampal long-term potentiation and cognitive behaviors in mice. Brain research\| PubMed ID: 20932954	2010
Implications for treatment: GABAA receptors in aging, Down syndrome and Alzheimer's disease. Journal of neurochemistry\| PubMed ID: 21388375	2011
Comprehensive behavioral phenotyping of Ts65Dn mouse model of Down syndrome: activation of β1-adrenergic receptor by xamoterol as a potential cognitive enhancer. Neurobiology of disease\| PubMed ID: 21527343	2011
Enantioselective synthesis of (-)-jiadifenin, a potent neurotrophic modulator. Organic letters\| PubMed ID: 21812392	2011
Mouse models for Down syndrome-associated developmental cognitive disabilities. Developmental neuroscience\| PubMed ID: 21865664	2011
Increased efficiency of the GABAA and GABAB receptor-mediated neurotransmission in the Ts65Dn mouse model of Down syndrome. Neurobiology of disease\| PubMed ID: 22062771	2012
Genetic analysis of Down syndrome facilitated by mouse chromosome engineering. Bioengineered bugs\| PubMed ID: 22126738	2012
Cognitive and pharmacological insights from the Ts65Dn mouse model of Down syndrome. Current opinion in neurobiology\| PubMed ID: 22658745	2012
Deficits in cognition and synaptic plasticity in a mouse model of Down syndrome ameliorated by GABAB receptor antagonists. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 22764230	2012
Potential use of γ-secretase modulators in the treatment of Alzheimer disease. Archives of neurology\| PubMed ID: 22801784	2012
Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome. Nature medicine\| PubMed ID: 23524343	2013
Illicium sesquiterpenes: divergent synthetic strategy and neurotrophic activity studies. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 23526661	2013
Aging and intellectual disability: Insights from mouse models of down syndrome. Developmental disabilities research reviews\| PubMed ID: 23949828	2013
Human chromosome 21 orthologous region on mouse chromosome 17 is a major determinant of Down syndrome-related developmental cognitive deficits. Human molecular genetics\| PubMed ID: 24041763	2014
The challenge of connecting the dots in the B.R.a.I.N. Neuron\| PubMed ID: 24139032	2013
Soluble γ-Secretase Modulators Selectively Inhibit the Production of the 42-Amino Acid Amyloid β Peptide Variant and Augment the Production of Multiple Carboxy-Truncated Amyloid β Species. Biochemistry\| PubMed ID: 24401146	2014