Topical Collections

Skeletal and cardiac muscle weakness affects a large group of individuals worldwide and represents a major cause of reduced quality of life and mortality. Development of personalized treatment strategies to prevent and cure muscle weak...

Neurodegenerative diseases including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, and frontotemporal dementia are devastating disorders with no known cure, mainly due to lack of underst...

In 2017 the Nobel prize in chemistry was awarded "for developing cryo-electron microscopy (cyroEM) for the high-resolution structure determination of biomolecules in solution." The field has quickly responded with a flurry of growth. C...

Atopic dermatitis is a chronic, inflammatory dermatological disorder that can affect individuals across all age groups. It significantly impairs patients' quality of life. The persistent symptoms and conspicuous skin lesions often lead...

Arrhythmias are very common and clinically highly relevant because they are associated with substantial morbidity and mortality. Over the recent years, the underlying pathophysiology has been studied intensively and numerous advances h...

In recent decades, the application of new molecular and cellular techniques in avian embryos has opened up new avenues to understanding various biological questions in birds, including chickens (Gallus gallus). Questions include, how c...

With support from new equipment and new concepts, many new technologies continue to be developed for diagnosis and treatment in clinical medicine. New surgical techniques and new concepts of perioperative support are constantly being d...

In the face of mounting environmental, economic, and societal challenges, the integration of artificial intelligence (AI) and machine learning (ML) for sustainability efforts has emerged as a transformative approach. This Methods Colle...

The transforming growth factor-β (TGF-β) family of growth and differentiation factors are pleiotropic cytokines that elicit a broad spectrum of cellular effects on many different cell types. They perform critical roles in embryogenesis...

Minimally invasive pancreatic surgery is on the rise worldwide. Minimally invasive distal pancreatectomy (MIDP) has been reported to be superior to open distal pancreatectomy (ODP) in terms of blood loss and hospital stay. The oncologi...

Non-pharmacological therapies of traditional Chinese medicine are widely used to treat diseases in China and even globally. Standard non-pharmacological therapies include but are not limited to acupuncture, tuina, moxibustion, and cupp...

The ovarian reserve represents the fertility potential for every woman and is defined as the population of quiescent follicles within the ovary. Initiation of the resting follicle pool commences in the fetus, then experiences a progres...

Microorganisms are versatile agents that modify and shape the environment in which we live. Because they have a very diverse metabolic repertoire, there is a significant gap in knowledge on the nutritional needs of keystone microorgani...

Platelet biogenesis is a fascinating cell biological process. Platelets arise from the cytoplasmic fragmentation of their large marrow precursor, the megakaryocyte (MK). MKs are derived from hematopoietic stem cells and undergo a uniqu...