SUBJECTS
Studying Lung Structure and Function Using Pulmonary MRI
Historically, the use of MRI in the lungs has been limited by the challenges of low tissue density, respiratory and cardiac motion, and the fast relaxation time of MRI signal intensity. However, recent improvements to MRI acquisition m...
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Current methods in chick embryology
In recent decades, the application of new molecular and cellular techniques in avian embryos has opened up new avenues to understanding various biological questions in birds, including chickens (Gallus gallus). Questions include, how c...
State-of-the-Art Methodologies to Functionally Characterize Cardiac and Skeletal Muscle from the Myofibril Level to Intact Muscle
Skeletal and cardiac muscle weakness affects a large group of individuals worldwide and represents a major cause of reduced quality of life and mortality. Development of personalized treatment strategies to prevent and cure muscle weak...
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Translational Cardiac Electrophysiology
Arrhythmias are very common and clinically highly relevant because they are associated with substantial morbidity and mortality. Over the recent years, the underlying pathophysiology has been studied intensively and numerous advances h...
Cellular Models of Neurodegeneration
Neurodegenerative diseases including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, and frontotemporal dementia are devastating disorders with no known cure, mainly due to lack of underst...
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Atopic Dermatitis: Tools for Faster Remission and Lesser Relapse
Atopic dermatitis is a chronic, inflammatory dermatological disorder that can affect individuals across all age groups. It significantly impairs patients' quality of life. The persistent symptoms and conspicuous skin lesions often lead...
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Established Methods and Innovative Approaches to Cryo Electron Microscopy
In 2017 the Nobel prize in chemistry was awarded "for developing cryo-electron microscopy (cyroEM) for the high-resolution structure determination of biomolecules in solution." The field has quickly responded with a flurry of growth. C...
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Innovative Technologies in Clinical Medicine
With support from new equipment and new concepts, many new technologies continue to be developed for diagnosis and treatment in clinical medicine. New surgical techniques and new concepts of perioperative support are constantly being d...
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Innovations of AI and ML for Sustainability
In the face of mounting environmental, economic, and societal challenges, the integration of artificial intelligence (AI) and machine learning (ML) for sustainability efforts has emerged as a transformative approach. This Methods Colle...
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Transcatheter Therapies for Structural Heart Diseases
The incidence of valvular heart diseases, which are responsible for a high rate of morbidity and mortality worldwide, increases with age. Until recently, the only treatment option was surgery. With the advent of transcatheter solutions...
Current Methods in Astyanax mexicanus Research
The Mexican Tetra, Astyanax mexicanus is an excellent model organism to study the developmental and genetic basis of evolution. This species of fish consists of a river-dwelling (surface) population and a number of cave-dwelling popula...
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Preclinical Models and Imaging Modalities of Tumor Microenvironment in Metastasis
Cancer research has focused on the cancer cell, its proliferation rates, apoptosis resistance, mutation rates, sensitivity to radio and chemotherapy. However, tumor metastatic progression involves many other cellular and molecular play...
Mechanical Modelling of Viscoelastic Materials
Viscoelastic behaviors are common in polymers, composites, geological materials, biomaterials, and even metals. Viscoelastic mechanics focus on the time-dependent mechanical characteristics, constitutive relation, and failure process o...
Methods for Studying TGF-β Family Signaling in Development and Disease
The transforming growth factor-β (TGF-β) family of growth and differentiation factors are pleiotropic cytokines that elicit a broad spectrum of cellular effects on many different cell types. They perform critical roles in embryogenesis...
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Biotechniques for the Study of Microbial Virulence Factors
Infectious diseases have always been a significant challenge to global public health, and the pandemic caused by the novel coronavirus (SARS-CoV2) has once again sounded the alarm. Bacteria are one of the most important pathogens of in...